Reversal by glucocorticoid hormones of the loss of a fibronectin and probollagen matrix around transformed human cells.

[en] Confluent cultured human skin fibroblasts had an extracellular fibrillar matrix of fibronectin and procollagen. Human skin fibroblasts transformed by SV40 did not have such a matrix. Treatment of transformed fibroblasts with 10(-5) to 10(-8) M dexamethasone and 10(-5) to 10(-7) M cortisol, but not testosterone or progesterone, caused partial restoration of the matrix. Glucocorticoid-treated transformed human fibroblasts can serve as a model for partial reversion toward normal or differentiation of transformed human fibroblasts.

Disciplines :

Biochemistry, biophysics & molecular biology

Author, co-author :

Furcht, L. T.

Mosher, D. F.

Wendelschafer-Crabb, G.

Foidart, Jean-Michel ; Université de Liège - ULiège > Département des sciences cliniques > Gynécologie - Obstétrique - Labo de biologie des tumeurs et du développement

Language :

English

Title :

Reversal by glucocorticoid hormones of the loss of a fibronectin and probollagen matrix around transformed human cells.

Publication date :

1979

Journal title :

Cancer Research

ISSN :

0008-5472

eISSN :

1538-7445

Publisher :

American Association for Cancer Research, Inc. (AACR), Baltimore, United States - Maryland

Volume :

Issue :

6Pt 1

Pages :

2077-83

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 01 February 2011

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