[en] Background Ectopic abnormal parathyroid glands are relatively
common in the superior mediastinum but are rarely
situated in the aortopulmonary window (APW). The embryological
origin of these abnormal parathyroid glands is controversial.
The purpose of this investigation was to investigate
the embryological origin and the surgical management of
abnormal parathyroid glands situated in the APW.
Methods The databases of patients operated on for primary,
secondary, and tertiary hyperparathyroidism at eight
European medical centers with a special interest in endocrine
surgery were reviewed to identify those with APW adenomas.
Demographic features, localization procedures, and
perioperative and pathology findings were documented. The
embryological origin was determined based on the number
and position of identified parathyroid glands.
Results Nineteen (0.24%) APW parathyroid tumors were
identified in 7,869 patients who underwent an operation for
hyperparathyroidism (HPT) and 181 patients (2.3%) with
mediastinal abnormal parathyroid glands. Ten patients had
primary, eight had secondary, and one had tertiary HPT.
Sixteen patients had undergone previous unsuccessful cervical
exploration. In three patients, an APW adenoma was
suspected by preoperative localization studies and was cured
at the initial operation. Sixteen patients had persistent HPTof
whom 15 were reoperated, resulting in 6 failures. Evaluation
of 17 patients who had bilateral neck exploration allowed us
to determine the most probable origin of the APW parathyroid
tumors: 12 were supernumerary, 4 appeared to originate
from a superior, and 1 from an inferior gland.
Conclusions Abnormal parathyroid glands situated in the
APW are rare and usually identified after an unsuccessful
cervical exploration. Preoperative imaging of the mediastinum
and neck are essential. The origin of these ectopically
situated tumors is probably, as suggested by our data, from a
supernumerary fifth parathyroid gland or from abnormal
migration of a superior parathyroid gland during the
embryologic development.
Disciplines :
Surgery
Author, co-author :
Arnault, Vincent
Beaulieu, Anthony
Lifante, Jean-Christophe
Sitges Serra, Antonio
Sebag, Frederic
Mathonnet, Muriel
Hamy, Antoine
Meurisse, Michel ; Université de Liège - ULiège > Chirurgie abdominale- endocrinienne et de transplantation
Carnaille, Bruno
Kraimps, Jean Louis
Language :
English
Title :
Multicenter Study of 19 Aortopulmonary Window parathyroid Tumors : The callenge of Embryologic origin
Publication date :
2010
Journal title :
World Journal of Surgery
ISSN :
0364-2313
eISSN :
1432-2323
Publisher :
Springer Verlag, New York, United States - New York
Akerstro?m G, Malmaeus J, Bergstrom R (1984) Surgical anatomy of human parathyroid glands. Surgery 95:14-21
Clark O (1988) Mediastinal parathyroid tumors. Arch Surg 123:1096-1100
Shen W, Duren M, Morita E, Higgins C, Duh QY, Siperstein A (1996) Reoperation for persistent or recurrent primary hyperparathyroidism. Arch Surg 131:861-869
Henry JF, Defechereux T, Raffaelli M, Lubrano D, Iacobone M (2000) Supernumerary ectopic hyperfunctioning parathyroid gland: a potential pitfall in surgery for sporadic primary hyperparathyroidism. Ann Chir 125:247-252
Pattou F, Pellissier L, Noel C, Wambergue F, Huglo D, Proye C (2000) Supernumerary parathyroid glands: frequency and surgical significance in treatment of renal hyperparathyroidism. Word J Surg 24:1330-1334
Russel CF, Grant CS, Van Heerden JA (1982) Hyperfunctionning supernumerary parathyroid glands. Mayo Clin Proc 57:121-124
Thompson NW, Eckauser FE, Harness JK (1982) The anatomy of primary hyperparathyroidism. Surgery 92:814-821
Wang C (1977) Parathyroid re-exploration: a clinical and pathological study of 112 cases. Ann Surg 186:140-145
McHenry C, Walsh M, Jarosz H, Henkin R, Tope J, Lawrence A et al (1988) Resection of parathyroid tumor in the aortopulmonary window without prior neck exploration. Surgery 104:1090- 1094
Russel CF, Edis AJ, Scholz DA, Sheedy PF, Van Heerden JA (1981) Mediastinal parathyroid tumors. Experience with 38 tumors requiring mediastinotomy for removal. Ann Surg 193:805-809
Kang Y, Rosen K, Clark O, Higgins C (1993) Localization of abnormal parathyroid glands of the mediastinum with MR imaging. Radiology 189:137-141
Prinz RA, Lonchyna V, Carnaille B, Wurtz A, Proye C (1994) Thoracoscopic excision of enlarged mediastinal parathyroid glands. Surgery 116:999-1004
Knight R, Ratzer E, Fenoglio M, Moore J (1997) Thoracoscopic excision of mediastinal parathyroid adenomas: a report of two cases and review of the literature. J Am Coll Surg 185:499-503
Liu R, Hill M, Ryan J (2005) One-gland exploration for mediastinal parathyroid adenomas: cervical and thoracoscopic approaches. Am J Surg 189:601-605
Peix JL, Van Box Som P, Clayes K, Lapras V (1996) Excision of a parathyroid adenoma of the aorto-pulmonary window under thoracoscopy. Presse Med 25:494-496
Ravipati NB, McLemore EC, Schlinkert RT, Arqueta R (2008) Anterior mediastinotomy for parathyroidectomy. Am J Surg 195:799-802
Bauer W, Federman DD (1962) Hyperparathyroidism epitomized: the case of Captain Charles E. Martell Metabolism 11:21- 29
Cohn KH, Silen W (1982) Lessons of parathyroid reoperation. Am J Surg 144:511-517
Barbier J, Henry JF (1991) Primary hyperparathyroidism. Report of the 93rd French Congress of Surgery. Springer, Paris, France
Norris EH (1937) The parathyroid glands and the lateral thyroid in man: their morphogenesis, histogenesis, topographic anatomy and prenatal growth. Contrib Embryol 159:249
Cope O (1941) Surgery of hyperparathyroidism: the occurence of parathyroid glands in the anterior medisatinum and the division of operation in two stages. Ann Surg 114:706-733
Prinz R, Lonchyna V, Carnaille B, Wurtz A, Proye C (1994) Thoracoscopic excision of enlarged mediastinal parathyroid glands. Surgery 116:999-1005
Doppman J, Skarulis M, Chen C, Chang R, Pass H, Fraker D et al (1996) Parathyroid adenomas in the aortopulmonary window. Radiology 201:456-462
Curley IR, Wheeler MH, Thompson NW, Grant CS (1988) The challenge of the middle mediastinal parathyroid. World J Surg 12:818-824
Dubost C, Bedig G, Gossot D, Sarfati E (1987) Adenoma of the middle mediastinum clearly visible at scintigraphy. Presse Med 16:176
Lennquist S. Discussion of Levin KE, Gooding GAW, Okerlund M et al (1987) Localizing studies in patients with persistent or recurrent hyperparathyroidism. Surgery 102:917-925
Obara T, Fujimoto Y, Tanaka R et al (1990) Mid-mediastinal parathyroid lesions: preoperative localization and surgical approach in two cases. Jpn J Surg 20:481-486
Obara T, Fujimoto Y, Ito Y (1992) Primary hyperparathyroidism in patients with multiple endocrine neoplasia type I: experience by a single surgical team in Japan. Henry Ford Hosp Med J 40:191-194
Proye C, Lefebvre J, Bourdelle-Hego MF, Francois M, Carnaille B, Foucher C et al (1988) Middle mediastinal parathyroid adenoma of the aorto-pulmonary window: 2 cases. Chirurgie 114:166-173
Stocks AE, Hartley LCJ (1986) Hypercalcemia: the case of the missing adenoma. Med J Aust 145:92-94
Thule P, Thakore K, Vasant J, McGarity W, Weber C, Phillips LS (1994) Preoperative localization of parathyroid tissue with technetium- 99m sestamibi 123I subtraction scanning. J Clin Endocrinol Metab 78:77-82
Weber CJ, Vansant J, Alazraki N, Christy J, Watts N, Phillips LS et al (1993) Value of technetium 99m sestamibi/iodine-123 imaging in reoperative parathyroid surgery. Surgery 114:1011- 1018
Mariette C, Pellissier L, Combemale F, Quievreux JL, Carnaille B, Proye C (1998) Reoperation for persistent or recurrent primary hyperparathyroidism. Langenbeck's Arch Surg 383:174-179
Aly A, Douglas M (2003) Embryonic parathyroid rests occur commonly and have implications in the management of secondary hyperparathyroidism. ANZ J Surg 73:284-288
Gilmour JR (1937) Embryology of the parathyroid glands and thymus and certain associated rudiments. J Pathol Bacteriol XLV, 507
Frazer JE (1923) The nomenclature of diseased states caused by certains vestigial structures in the neck. Br J Surg 11:131-136
Bodner J, Profanter C, Prommegger R, Greiner A, Margreiter R, Schmid T (2004) Mediastinal parathyroidectomy with the Da Vinci robot: presentation of a new technique. J Thorac Cardiovasc Surg 127:1831-1832
Boushey R, Todd T (2001) Middle mediastinal parathyroid: diagnosis and surgical approach. Ann Thorac Surg 71:699-701
Deleplanque G, Kraimps JL, Coste G, Carretier M, Barbier J (1989) Case report of a parathyroid adenoma located in the middle mediastinum. Ann Chir 43:393-396