Reference : Bacterial Active-Site Serine Penicillin-Interactive Proteins and Domains: Mechanism, ...
Scientific journals : Article
Life sciences : Microbiology
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/2268/81285
Bacterial Active-Site Serine Penicillin-Interactive Proteins and Domains: Mechanism, Structure, and Evolution
English
Ghuysen, Jean-Marie [Université de Liège - ULiège > Institut de Chimie > Service de Microbiologie > > >]
1988
Reviews of Infectious Diseases
University of Chicago Press
10
4
726-732
Yes (verified by ORBi)
International
0162-0886
Chicago
IL
[en] Acyltransferases/metabolism* ; Bacterial Proteins* ; Binding Sites ; Carrier Proteins/metabolism* ; Chemical Phenomena ; Chemistry ; Hexosyltransferases/metabolism* ; Hydrolysis ; Multienzyme Complexes/metabolism* ; Muramoylpentapeptide Carboxypeptidase/metabolism* ; Penicillin-Binding Proteins ; Peptidyl Transferases/metabolism* ; beta-Lactamases/metabolism*
[en] The bacterial active-site serine penicillin-hydrolyzing and penicillin-binding proteins or domains operate by a serine-ester-linked acyl enzyme mechanism similar to that of the peptidases of the trypsin and subtilisin families. On the basis of known primary and tertiary structures, predictive studies support the view that these proteins or domains form a superfamily of evolutionarily related enzymes. Although--depending on the evolutionary distance--they may have very different amino acid sequences and distinct functional characteristics and specificities, they all would have conserved the same unprecedented type of polypeptide scaffolding. When obtained, complete structural information should provide the necessary tools for the rational design of novel types of inactivators of these important enzyme targets.
Researchers ; Professionals
http://hdl.handle.net/2268/81285
also: http://hdl.handle.net/2268/91721

File(s) associated to this reference

Fulltext file(s):

FileCommentaryVersionSizeAccess
Open access
GHUYSEN_1988_bacterial-active-sites-serine--penicillin.pdfPublisher postprint532.84 kBView/Open

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.