Reference : Identification of BlaR, the signal transducer for β-lactamase production in Bacillus ...
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/2268/81269
Identification of BlaR, the signal transducer for β-lactamase production in Bacillus licheniformis, as a penicillin-binding protein with strong homology to the OXA-2 β-lactamase (class D) of Salmonella typhimurium
English
Zhu, Ying-Fang [The State University of New Jersey > Waksman Institute > > >]
Curran, Ivan H. A. [The State University of New Jersey > Waksman Institute > > >]
Joris, Bernard mailto [Université de Liège - ULiège > Département des sciences de la vie > Physiologie et génétique bactériennes - Centre d'ingénierie des protéines >]
Ghuysen, Jean-Marie [Université de Liège - ULiège > Institut de Chimie > Service de Microbiologie > >]
Lampen, J. Oliver [Université de Liège - ULiège > Institut de Chimie > Service de Microbiologie > >]
1-Feb-1990
Journal of Bacteriology
American Society for Microbiology (ASM)
172
2
1137-1141
Yes (verified by ORBi)
International
0021-9193
1098-5530
Washington
DC
[en] amino acid sequence ; bacillus/enzymology/*genetics/metabolism ; bacterial proteins ; carrier proteins/*genetics/metabolism ; enzyme induction ; genes, bacterial ; genetic vectors ; hexosyltransferases ; molecular sequence data ; muramoylpentapeptide carboxypeptidase/*genetics/metabolism ; penicillin-binding proteins ; peptidyl transferases ; restriction mapping ; salmonella typhimurium/enzymology/*genetics ; sequence homology, nucleic acid ; signal transduction ; beta-Lactamases/*biosynthesis/*genetics
[en] The blaR gene of Bacillus licheniformis encodes the signal transducer for induction of the class A beta-lactamase. The protein product, BlaR, has a hydrophilic carboxy region that binds beta-lactams and shows high sequence homology to the class D beta-lactamases, particularly the OXA-2 beta-lactamase of Salmonella typhimurium. The BlaR-beta-lactam complex is stable and may provide the continuing stimulus needed for the prolonged production of the enzyme.
Centre d'ingénierie des protéines - CIP
Researchers ; Professionals
http://hdl.handle.net/2268/81269

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