Reference : Estradiol and Progesterone Regulate the Proliferation of Human Breast Epithelial Cells
Scientific journals : Article
Human health sciences : Reproductive medicine (gynecology, andrology, obstetrics)
Estradiol and Progesterone Regulate the Proliferation of Human Breast Epithelial Cells
Foidart, Jean-Michel mailto [Université de Liège - ULiège > Département des sciences cliniques > Gynécologie - Obstétrique - Labo de biologie des tumeurs et du développement >]
Colin, Carine [ > > ]
Denoo, Xavier [ > > ]
Desreux, Joëlle mailto [Université de Liège - ULiège > > Sénologie >]
Beliard, Aude mailto [Université de Liège - ULiège > > Gynécologie-Obstétrique CHR >]
Fournier, Sbine [ > > ]
de Lignieres, Bruno [ > > ]
Fertility and Sterility
Yes (verified by ORBi)
New York
[en] Human ; in vivo ; normal breas ; progesterone ; estradiol percutaneous administration ; steroid concentration ; proliferation markers ; proliferating cell nuclear antigen ; mitotic index ; DNA ploidy
[en] OBJECTIVE: To study the effects of estradiol and progesterone on the proliferation of normal human breast epithelial cells in vivo. DESIGN: Double-blind randomized study. SETTING: Departments of gynecology and of cell biology at a university hospital. PATIENT(S): Forty postmenopausal women with untreated menopause and documented plasma FSH levels of >30 mIU/mL and estradiol levels of <20 pg/mL. INTERVENTION(S): Daily topical application to both breasts of a gel containing a placebo, estradiol, progesterone, or a combination of estradiol and progesterone during the 14 days preceding esthetic breast surgery or excision of a benign lesion. MAIN OUTCOME MEASURE(S): Plasma and breast tissue concentrations of estradiol and progesterone. Epithelial cell cycles were evaluated in normal breast tissue by counting mitoses and performing quantitative proliferating cell nuclear antigen immunolabeling analyses. RESULT(S): Increasing the estradiol concentration enhanced the number of cycling epithelial cells, whereas increasing the progesterone concentration significantly limited the number of cycling epithelial cells. CONCLUSION(S): Exposure to progesterone for 14 days reduced the estradiol-induced proliferation of normal breast epithelial cells in vivo.

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