Article (Scientific journals)
Molecular Biology of Bovine Herpesvirus Type 4
Thiry, Etienne; Bublot, M.; Dubuisson, J. et al.
1992In Veterinary Microbiology, 33 (1-4), p. 79-92
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Abstract :
[en] Bovine herpesvirus type 4 (BHV-4) is a ubiquitous virus of cattle. Its genome is a 144 +/- 6 kb double-stranded DNA consisting of a unique central part (L-DNA) flanked at both ends by tandem repeats called polyrepetitive DNA (prDNA or H-DNA). The overall arrangement of genes has been obtained by the analysis of homologies between short BHV-4 DNA sequences and corresponding genes of Epstein-Barr virus (EBV) and herpesvirus saimiri (HVS). The gene expression is temporally regulated. Glycoprotein precursor p (gp10/gp17) is expressed as gamma 1 polypeptide. Glycoproteins gp1, gp8, gp11 and their precursors are gamma 2 proteins. The analysis of strain variations allows the definition of two types of strains, based on the DNA patterns: the Movar 33/63-like and the DN 599-like strains. Only the M40 strain, isolated in India, fails to fit this classification. The genomic variations have been compiled to build a dendrogram showing three levels of divergence between BHV-4 strains or isolates. The available molecular data indicate that the BHV-4 genome shares much similarity with the DNA of EBV and HVS, two representative members of the gammaherpesvirinae. BHV-4 may therefore be classified in the subfamily gammaherpesvirinae.
Disciplines :
Microbiology
Veterinary medicine & animal health
Author, co-author :
Thiry, Etienne ;  Université de Liège - ULiège > Département des maladies infectieuses et parasitaires > Virologie, épidémiologie et pathologie des maladies virales
Bublot, M.
Dubuisson, J.
Van Bressem, M. F.
Lequarré, Anne-Sophie ;  Université de Liège - ULiège > Département de productions animales > Génomique animale
Lomonte, P.
Vanderplasschen, Alain ;  Université de Liège - ULiège > Immunologie et vaccinologie
Pastoret, Paul-Pierre ;  Université de Liège - ULiège > Département des maladies infectieuses et parasitaires > Département des maladies infectieuses et parasitaires
Language :
English
Title :
Molecular Biology of Bovine Herpesvirus Type 4
Publication date :
November 1992
Journal title :
Veterinary Microbiology
ISSN :
0378-1135
eISSN :
1873-2542
Publisher :
Elsevier, Netherlands
Volume :
33
Issue :
1-4
Pages :
79-92
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 05 March 2009

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