Ent-Trachyloban-3beta-ol, a new cytotoxic diterpene frm Croton zambesicus

Antineoplastic Agents, Phytogenic/chemistry/isolation & purification/pharmacology; Cell Line; Croton/chemistry; Diterpenes/chemistry/isolation & purification/pharmacology; Drug Screening Assays, Antitumor; Hela Cells; Humans; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Plant Leaves/chemistry

Abstract :

[en] The dichloromethane extract of leaves of Croton Zambesicus (Euphorbiaceae) showing in vitro cytotoxicity against huma cervix carcinoma cells was investigated in order to identify its active compounds. A bio-guided fractionation by HSCCC followed by MPLC led us to isolate a trachylobane diterpene, ent-trachyloban-3beta-ol, with cytotoxic properties (IC50 on HeLa cells = 7.3 ùg/ml). This is the first report on the cytotoxicity of a trachylobane diterpene.

Disciplines :

Life sciences: Multidisciplinary, general & others

Author, co-author :

Block, Sebastien

Stevigny, Caroline

De Pauw-Gillet, Marie-Claire ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Histologie - Cytologie - Département des sciences biomédicales et précliniques

de Hoffmann E

Llabres, Gabriel ; Université de Liège - ULiège > Département de physique > Département de physique

Adjakidje, V.

Quetin-Leclercq, Joelle

Language :

English

Title :

Ent-Trachyloban-3beta-ol, a new cytotoxic diterpene frm Croton zambesicus

Publication date :

2002

Journal title :

Planta Medica

ISSN :

0032-0943

eISSN :

1439-0221

Publisher :

Georg Thieme Verlag, Germany

Volume :

Pages :

647-649

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 24 November 2010

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