Reference : Cytotoxic aporphine alkaloids from Cassytha filiformis.
Scientific journals : Article
Life sciences : Multidisciplinary, general & others
Cytotoxic aporphine alkaloids from Cassytha filiformis.
Stevigny, C. [> > > >]
Block, S. [> > > >]
De Pauw-Gillet, Marie-Claire mailto [Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Histologie - Cytologie - Département des sciences biomédicales et précliniques >]
de Hoffmann, E. [> > > >]
Llabres, Gabriel mailto [Université de Liège - ULiège > Département de physique > Département de physique >]
Adjakidje, V. [> > > >]
Quetin-Leclercq, J. [> > > >]
Planta Medica
Georg Thieme Verlag Stuttgart
Yes (verified by ORBi)
New York
[en] 3T3 Cells/drug effects ; Animals ; Aporphines/chemistry/pharmacology ; Female ; HL-60 Cells/drug effects ; Hela Cells/drug effects ; Humans ; Inhibitory Concentration 50 ; Lauraceae ; Magnetic Resonance Spectroscopy ; Mice ; Phytotherapy ; Plant Extracts/chemistry/pharmacology ; Tumor Cells, Cultured/drug effects
[en] Purification of a cytotoxic crude alkaloid extract of Cassytha filiformis led to the isolation of four known aporphine alkaloids: neolitsine, dicentrine, cassythine (= cassyfiline) and actinodaphnine. Their structures were determined by analysis of spectroscopic data. All isolated alkaloids were tested for their cytotoxic activities on cancer and non-cancer cell lines in vitro. Neolitsine was the most active against HeLa and 3T3 cells (IC 50 :21.6 microM, and 21.4 microM, respectively). Cassythine and actinodaphnine showed the highest activity against Mel-5 (IC 50 : 24.3 microM and 25.7 microM, respectively) and HL-60 (IC 50 : 19.9 microM and 15.4 microM, respectively). This is the first report on the cytotoxic activity of C. filiformis extract and of neolitsine and cassythine. Furthermore, the complete NMR data of cassythine and actinodaphnine are given here for the first time.

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