Article (Scientific journals)
The spinal cord ependymal region: A stem cell niche in the caudal central nervous system
Hugnot, Jean-Philippe; Franzen, Rachelle
2011In Frontiers in Bioscience: A Journal and Virtual Library, (16), p. 1044-1059
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Keywords :
Spinal cord; stem cells; ependyma
Abstract :
[en] In the brain, specific signalling pathways localized in highly organized regions called niches, allow the persistence of a pool of stem and progenitor cells that generate new neurons and glial cells in adulthood. Much less is known on the spinal cord central canal niche where a sustained adult neurogenesis is not observed. Here we review our current knowledge of this caudal niche in normal and pathological situations. Far from being a simple layer of homogenous cells, this region is composed of several cell types localized at specific locations, expressing characteristic markers and with different morphologies and functions. We further report on a screen of online geneexpression databases to better define this spinal cord niche. Several genes were found to be preferentially expressed within or around the central canal region (Bmp6, CXCR4, Gdf10, Fzd3, Mdk, Nrtn, Rbp1, Shh, Sox4, Wnt7a) some of which by specific cellular subtypes. In depth characterization of the spinal cord niche constitutes a framework to make the most out of this endogenous cell pool in spinal cord disorders.
Disciplines :
Neurosciences & behavior
Author, co-author :
Hugnot, Jean-Philippe
Franzen, Rachelle  ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Neuro-anatomie
Language :
English
Title :
The spinal cord ependymal region: A stem cell niche in the caudal central nervous system
Publication date :
2011
Journal title :
Frontiers in Bioscience: A Journal and Virtual Library
ISSN :
1093-9946
eISSN :
1093-4715
Publisher :
Frontiers in Bioscience Publications, Tampa, United States - Florida
Issue :
16
Pages :
1044-1059
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 24 November 2010

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