Bovine herpesvirus 1 glycoprotein D expression in bovine upper respiratory tract mediated by a human adenovirus type 5

[en] Bovine herpesvirus 1 glycoprotein D (gD) gene expression by recombinant replication defective human adenovirus type 5 (HAdV-5) was investigated in calves using indirect immunofluorescence microscopy (IIFM), confocal laser scanning microscopy (CLSM) and RT-PCR. One fold intranasal instillation of HAdV-5-expressing gD in the cattle upper respiratory tract showed a short term expression of at least 5 days, but not 10 days, limited only to epithelial cells localised in the epithelium of the nasal mucosa in one out of six calves. Observed limited gene transfer into well differentiated cattle airway epithelial cells must be taken into consideration in order to enhance transfection efficiency, and consequently the vaccine potential of this vector.

Disciplines :

Veterinary medicine & animal health

Author, co-author :

Gogev, S.

Georgin, J. P.

Schynts, F.

Vanderplasschen, Alain ; Université de Liège - ULiège > Immunologie et vaccinologie

Thiry, Etienne ; Université de Liège - ULiège > Département des maladies infectieuses et parasitaires > Virologie, épidémiologie et pathologie des maladies virales

Language :

English

Title :

Bovine herpesvirus 1 glycoprotein D expression in bovine upper respiratory tract mediated by a human adenovirus type 5

Publication date :

2004

Journal title :

Veterinary Research

ISSN :

0928-4249

eISSN :

1297-9716

Publisher :

E D P Sciences, Les Ulis Cedex A, France

Volume :

Issue :

6, Nov-Dec

Pages :

715-721

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 04 March 2009

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