Bovine herpesvirus 1 infection and infectious bovine rhinotracheitis

[en] Bovine herpesvirus 1 (BoHV-1), classified as an alphaherpesvirus, is a major pathogen of cattle. Primary infection is accompanied by various clinical manifestations such as infectious bovine rhinotracheitis, abortion, infectious pustular vulvovaginitis, and systemic infection in neonates. When animals survive, a life-long latent infection is established in nervous sensory ganglia. Several reactivation stimuli can lead to viral re-excretion, which is responsible for the maintenance of BoHV-1 within a cattle herd. This paper focuses on an updated pathogenesis based on a molecular characterization of BoHV-1 and the description of the virus cycle. Special emphasis is accorded to the impact of the latency and reactivation cycle on the epidemiology and the control of BoHV-1. Several European countries have initiated BoHV-1 eradication schemes because of the significant losses incurred by disease and trading restrictions. The vaccines used against BoHV-1 are described in this context where the differentiation of infected from vaccinated animals is of critical importance to achieve BoHV-1 eradication.

Disciplines :

Veterinary medicine & animal health

Author, co-author :

Muylkens, Benoît ; Université de Liège - ULiège > Département des maladies infectieuses et parasitaires > Virologie, épidémiologie et pathologie des maladies virales

Thiry, Julien ; Université de Liège - ULiège > Département des maladies infectieuses et parasitaires > Virologie, épidémiologie et pathologie des maladies virales

Kirten, P.

Schynts, F.

Thiry, Etienne ; Université de Liège - ULiège > Département des maladies infectieuses et parasitaires > Virologie, épidémiologie et pathologie des maladies virales

Language :

English

Title :

Bovine herpesvirus 1 infection and infectious bovine rhinotracheitis

Publication date :

2007

Journal title :

Veterinary Research

ISSN :

0928-4249

eISSN :

1297-9716

Publisher :

Edp Sciences S A, Les Ulis Cedex A, France

Volume :

Issue :

Pages :

181-209

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 04 March 2009

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330

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312

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237

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