Reference : The Influence of Phylogenic Origin on the Occurrence of Brachycephalic Airway Obstruc...
Scientific journals : Article
Life sciences : Veterinary medicine & animal health
The Influence of Phylogenic Origin on the Occurrence of Brachycephalic Airway Obstruction Syndrome in a Large Retrospective Study
[fr] Influence de la Phylogénie dans l'Apparition du Syndrome d'Obstruction Respiratoire des Chiens Brachycéphales
Njikam Nsangou, Ibrahim mailto [Université de Liège - ULiège > Services généraux (Faculté de médecine vétérinaire) > Scientifiques attachés au Doyen (F MV) - Département de productions animales >]
Huault, Maxime [ > > ]
Pirson, Vincent [ > > ]
Detilleux, Johann mailto [Université de Liège - ULiège > Département de productions animales > Génétique quantitative - Thériogenologie des animaux de production >]
International Journal of Applied Research in Veterinary Medicine
Veterinary Solutions LLC
Apopka, FL32704-2083
[en] Plylogenic - Dogs - BAOS - ; Brachycephalic - Genetic
[en] Strategies to identify genetic polymorphisms responsible for inherited disorders in purebred dog population are often based on experimental studies whereas hospitals case reports provide widely and easily affordable information of clinical significance. When this clinical information is enriched with knowledge on the phylogenetic origins, breed histories of the dog and adjusted for known biases, they may lead the way to more in depth genetic research. We illustrated here with a very complex disease, the brachycephalic airway obstruction syndrome (BAOS). No cases were reported in the boxer breed while almost half of the dogs from the other brachycephalic breeds of the same phylogenetic cluster were BAOS, making these breeds good candidates for further genetic studies. Critical issues to improve utility of clinical data for genetic studies are discussed along with methods to handle biases inherent to such type of studies.
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