B cell survival; Anergy; Bim; Itpkb; Lymphocyte selection
Abstract :
[en] Inositol 1,4,5-trisphosphate 3-kinase B (or Itpkb) and inositol 1,3,4,5-tetrakisphosphate (Ins(1,3,4,5)P4), its reaction product, play an important role in the control of B lymphocyte fate and function in vivo. In order to investigate the fine mechanisms of Itpkb and Ins(1,3,4,5)P4 action in B cells, we crossed Itpkb(-/-) mice with transgenic mice expressing a 3-83mudelta B cell receptor (BCR) specific for membrane-bound MHC-I H2-K(b) and H2-K(k) molecules. On a non-deleting H2-K(d) genetic background, we show that Itpkb is important for the control of Bim protein expression and B cell survival rather than for the control of B cell development from one stage to another. Analyses of cell surface markers expression, proapoptotic Bim protein expression, in vitro survival and in vivo turnover demonstrated that BCR transgenic Itpkb(-/-) B cells exhibit an anergic phenotype with the notable exception of their enhanced antigen-induced calcium signalling. On a deleting H2-K(b) genetic background, we show that Itpkb is not essential for BCR editing or negative selection. These data establish Itpkb as an important regulator of B cell survival and anergy in vivo.
Marechal, Yoann; Université Libre de Bruxelles - ULB > Institut de Recherches Interdisciplinaires en Biologie Humaine et Moléculaire (IRIBHM), Institut de Biologie et de Médecine Moléculaires (IBMM), Faculté de Médecine
Queant, Séverine; Université Libre de Bruxelles - ULB > Institut de Recherches Interdisciplinaires en Biologie Humaine et Moléculaire (IRIBHM), Institut de Biologie et de Médecine Moléculaires (IBMM), Faculté de Médecine
Polizzi, Séléna; Université Libre de Bruxelles - ULB > Institut de Recherches Interdisciplinaires en Biologie Humaine et Moléculaire (IRIBHM), Institut de Biologie et de Médecine Moléculaires (IBMM), Faculté de Médecine
Pouillon, Valérie; Université Libre de Bruxelles - ULB > Institut de Recherches Interdisciplinaires en Biologie Humaine et Moléculaire (IRIBHM), Institut de Biologie et de Médecine Moléculaires (IBMM), Faculté de Médecine
Schurmans, Stéphane ; Université de Liège - ULiège > Département de sciences fonctionnelles, Biochimie métabolique vétérinaire > et GIGA-Research
Language :
English
Title :
Inositol 1,4,5-trisphosphate 3-kinase B controls survival and prevents anergy in B cells
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Bibliography
Allman D., Srivastava B., Lindsley R.C. Alternative routes to maturity: branch points and pathways for generating follicular and marginal zone B cells. Immunol. Rev. 2004, 197:147-160.
Bell S.E., Vigorito E., McAdam S., Reynolds H.M., Caraux A., Colucci F., Turner M. PLCgamma2 regulates Bcl-2 levels and is required for survival rather than differentiation of marginal zone and follicular B cells. Eur. J. Immunol. 2004, 34:2237-2247.
Casellas R., Shih T.A., Kleinewietfeld M., Rakonjac J., Nemazee D., Rajewsky K., Nussenzweig M.C. Contribution of receptor editing to the antibody repertoire. Science 2001, 291:1541-1544.
Chiles T.C. Regulation and function of cyclin D2 in B lymphocyte subsets. J. Immunol. 2004, 173:2901-2907.
Culton D.A., O'Conner B.P., Conway K.L., Diz R., Rutan J., Vilen B.J., Clarke S.H. Early preplasma cells define a tolerance checkpoint for autoreactive B cells. J. Immunol. 2006, 176:790-802.
Daniel J., Marechal Y., Van G.F., Andris F., Leo O. Nicotinamide inhibits B lymphocyte activation by disrupting MAPK signal transduction. Biochem. Pharmacol. 2007, 73:831-842.
Eris J.M., Basten A., Brink R., Doherty K., Kehry M.R., Hodgkin P.D. Anergic self-reactive B cells present self antigen and respond normally to CD40-dependent T-cell signals but are defective in antigen-receptor-mediated functions. Proc. Natl. Acad. Sci. U.S.A. 1994, 91:4392-4396.
Foyouzi-Youssefi R., Arnaudeau S., Borner C., Kelley W.L., Tschopp J., Lew D.P., Demaurex N., Krause K.H. Bcl-2 decreases the free Ca2+ concentration within the endoplasmic reticulum. Proc. Natl. Acad. Sci. U.S.A. 2000, 97:5723-5728.
Fulcher D.A., Basten A. Reduced life span of anergic self-reactive B cells in a double-transgenic model. J. Exp. Med. 1994, 179:125-134.
Goodnow C.C., Crosbie J., Adelstein S., Lavoie T.B., Smith-Gill S.J., Brink R.A., Pritchard-Briscoe H., Wotherspoon J.S., Loblay R.H., Raphael K. Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice. Nature 1988, 334:676-682.
Jia Y., Subramanian K.K., Erneux C., Pouillon V., Hattori H., Jo H., You J., Zhu D., Schurmans S., Luo H.R. Inositol 1,3,4,5-tetrakisphosphate negatively regulates phosphatidylinositol-3,4,5-trisphosphate signaling in neutrophils. Immunity 2007, 27:453-467.
Lesley R., Xu Y., Kalled S.L., Hess D.M., Schwab S.R., Shu H.B., Cyster J.G. Reduced competitiveness of autoantigen-engaged B cells due to increased dependence on BAFF. Immunity 2004, 20:441-453.
Marechal Y., Pesesse X., Jia Y., Pouillon V., Perez-Morga D., Daniel J., Izui S., Cullen P.J., Leo O., Luo H.R., Erneux C., Schurmans S. Inositol 1,3,4,5-tetrakisphosphate controls proapoptotic Bim gene expression and survival in B cells. Proc. Natl. Acad. Sci. U.S.A. 2007, 104:13978-13983.
Meade J., Fernandez C., Turner M. The tyrosine kinase Lyn is required for B cell development beyond the T1 stage in the spleen: rescue by over-expression of Bcl-2. Eur. J. Immunol. 2002, 32:1029-1034.
Meffre E., Casellas R., Nussenzweig M.C. Antibody regulation of B cell development. Nat. Immunol. 2000, 1:379-385.
Melamed D., Kench J.A., Grabstein K., Rolink A., Nemazee D. A functional B cell receptor transgene allows efficient IL-7-independent maturation of B cell precursors. J. Immunol. 1997, 159:1233-1239.
Melamed D., Benschop R.J., Cambier J.C., Nemazee D. Developmental regulation of B lymphocyte immune tolerance compartmentalizes clonal selection from receptor selection. Cell 1998, 92:173-182.
Middendorp S., Hendriks R.W. Cellular maturation defects in Bruton's tyrosine kinase-deficient immature B cells are amplified by premature B cell receptor expression and reduced by receptor editing. J. Immunol. 2004, 172:1371-1379.
Miller A.T., Sandberg M., Huang Y.H., Young M., Sutton S., Sauer K., Cooke M.P. Production of Ins(1,3,4,5)P4 mediated by the kinase Itpkb inhibits store-operated calcium channels and regulates B cell selection and activation. Nat. Immunol. 2007, 8:514-521.
Miller A.T., Beisner D.R., Liu D., Cooke M.P. Inositol 1,4,5-trisphosphate 3-kinase B is a negative regulator of BCR signaling that controls B cell selection and tolerance induction. J. Immunol. 2009, 182:4696-4704.
Nemazee D.A., Burki K. Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class I antibody genes. Nature 1989, 337:562-566.
Oakes S.A., Scorrano L., Opferman J.T., Bassik M.C., Nishino M., Pozzan T., Korsmeyer S.J. Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulum. Proc. Natl. Acad. Sci. U.S.A. 2005, 102:105-110.
Oberdoerffer P., Novobrantseva T.I., Rajewsky K. Expression of a targeted lambda 1 light chain gene is developmentally regulated and independent of Ig kappa rearrangements. J. Exp. Med. 2003, 197:1165-1172.
Oliver P.M., Vass T., Kappler J., Marrack P. Loss of the proapoptotic protein, Bim, breaks B cell anergy. J. Exp. Med. 2006, 203:731-741.
Pinton P., Ferrari D., Magalhaes P., Schulze-Osthoff K., Di V.F., Pozzan T., Rizzuto R. Reduced loading of intracellular Ca(2+) stores and downregulation of capacitative Ca(2+) influx in Bcl-2-overexpressing cells. J. Cell Biol. 2000, 148:857-862.
Pouillon V., Hascakova-Bartova R., Pajak B., Adam E., Bex F., Dewaste V., Van L.C., Leo O., Erneux C., Schurmans S. Inositol 1,3,4,5-tetrakisphosphate is essential for T lymphocyte development. Nat. Immunol. 2003, 4:1136-1143.
Russell D.M., Dembic Z., Morahan G., Miller J.F., Burki K., Nemazee D. Peripheral deletion of self-reactive B cells. Nature 1991, 354:308-311.
Scorrano L., Oakes S.A., Opferman J.T., Cheng E.H., Sorcinelli M.D., Pozzan T., Korsmeyer S.J. BAX and BAK regulation of endoplasmic reticulum Ca2+: a control point for apoptosis. Science 2003, 300:135-139.
Su T.T., Guo B., Wei B., Braun J., Rawlings D.J. Signaling in transitional type 2 B cells is critical for peripheral B-cell development. Immunol. Rev. 2004, 197:161-178.
Turner M., Gulbranson-Judge A., Quinn M.E., Walters A.E., MacLennan I.C., Tybulewicz V.L. Syk tyrosine kinase is required for the positive selection of immature B cells into the recirculating B cell pool. J. Exp. Med. 1997, 186:2013-2021.
Wen B.G., Pletcher M.T., Warashina M., Choe S.H., Ziaee N., Wiltshire T., Sauer K., Cooke M.P. Inositol (1,4,5) trisphosphate 3 kinase B controls positive selection of T cells and modulates Erk activity. Proc. Natl. Acad. Sci. U.S.A. 2004, 101:5604-5609.
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