[en] Radiation Leukemia Virus (RadLV) is a retrovirus, which displays a highly specific thymotropism; after inoculation into young C57 BL/Ka mice, active virus replication is observed only in thymocytes and thymic lymphomas develop in most treated mice. The specific interaction between RadLV and the thymus resides in the particular susceptibility to infection of the most immature cells involved in the intrathymic lymphoid differentiation pathway and of non lymphoid thymic stromal cells. Recent data obtained from 'in situ' hybridization studies for detection of viral transcripts yield more detailed informations on these intriguing interactions.
Defresne, Marie-Paule ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Histologie - Cytologie
Language :
English
Title :
Radiation Leukemia Virus: A Marker for the Study of Intrathymic T Cell Differentiation
Publication date :
1989
Journal title :
Thymus
ISSN :
0165-6090
Publisher :
Kluwer Academic Publishers, Netherlands
Volume :
14
Issue :
1-3
Pages :
109-13
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
Fund for Medical Scientific Research CAC - Centre anticancéreux près l'Université de Liège asbl [BE] Bekales Foundation [BE] Braconnier-Lamarche Foundation