Reference : Maternal Blood Serum and Plasma Human Tumor-Associated Antigen RCAS1 During the Cours...
Scientific journals : Article
Human health sciences : Reproductive medicine (gynecology, andrology, obstetrics)
http://hdl.handle.net/2268/75473
Maternal Blood Serum and Plasma Human Tumor-Associated Antigen RCAS1 During the Course of Uncomplicated Pregnancies: A Prospective Study.
English
Tskitishvili, Ekaterine mailto [Université de Liège - ULiège > Département des sciences cliniques > Labo de biologie des tumeurs et du développement > > Osaka University Graduate School of Medicine, Department of Obstetrics and Gynecology >]
Sharentuya, Namuxila [Osaka University Graduate School of Medicine > Department of Obstetrics and Gynecology > > >]
Tsubouchi, Hiroaki [Osaka University Graduate School of Medicine > Department of Obstetrics and Gynecology > > >]
Kinugasa-Taniguchi, Yukiko [Osaka University Graduate School of Medicine > Department of Obstetrics and Gynecology > > >]
Kanagawa, Takeshi [Osaka University Graduate School of Medicine > Department of Obstetrics and Gynecology > > >]
Shimoya, Koichiro [Kawasaki Medical School > Department of Obstetrics and Gynecology > > >]
Tomimatsu, Takuji [Osaka University Graduate School of Medicine > Department of Obstetrics and Gynecology > > >]
Kimura, Tadashi [Osaka University Graduate School of Medicine > Department of Obstetrics and Gynecology > > >]
2010
American Journal of Reproductive Immunology
Blackwell
64
3
218-24
Yes (verified by ORBi)
International
1046-7408
1600-0897
Oxford
United Kingdom
[en] Maternal blood, ; plasma RCAS1 mRNA ; serum
[en] Citation Tskitishvili E, Sharentuya N, Tsubouchi H, Kinugasa-Taniguchi Y, Kanagawa T, Shimoya K, Tomimatsu T, Kimura T. Maternal blood serum and plasma human tumor-associated antigen RCAS1 during the course of uncomplicated pregnancies: a prospective study. Am J Reprod Immunol 2010; 64: 218-224 Problem We aimed to investigate the expression of the tumor-associated RCAS1 protein in maternal blood of uncomplicated pregnancies. Method of study Maternal blood was obtained from women with uncomplicated pregnancies (N = 43) at 11-13, 20-22, 32-34, 37-38 weeks of gestation, and immediately after delivery. Serum RCAS1 concentration was studied by ELISA, and plasma mRNA was subjected to real-time (RT)-PCR. Results Serum RCAS1 protein concentration was significantly up-regulated at 11-13 and 20-22 weeks than that at 32-34 weeks and after delivery. RCAS1 mRNA level was significantly increased at 11-13 weeks than that at 37-38 weeks. A significant positive correlation was defined between RCAS1 serum concentration at 11-13 weeks and gestational age at delivery and that between plasma RCAS1 mRNA levels at 37-38 weeks and umbilical cord blood base excess. A significant negative correlation was found between RCAS1 serum concentration at 37-38 weeks and umbilical cord blood pH at delivery. Conclusions RCAS1 protein might have importance in the development of uncomplicated pregnancies and for the prediction of pregnancy outcome.
Researchers ; Professionals ; Students
http://hdl.handle.net/2268/75473
10.1111/j.1600-0897.2010.00859.x
(c) 2010 John Wiley & Sons A/S.

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Maternal_blood_serum_and_plasma_human_tumor-associated_antigen_RCAS1_during_the_course_of_uncomplicated_pregnancies-_a_prospective_study.pdfThis is an electronic version (Author’s preprint) of the article published in American Journal of Reproductive Immunology, 2010 Sept 64(3):218-24 The original published version is available at:http://onlinelibrary.wiley.com/doi/10.1111/j.1600-0897.2010.00859.x/pdfAuthor preprint383.32 kBRequest copy

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