Article (Scientific journals)
Maternal Blood Serum and Plasma Human Tumor-Associated Antigen RCAS1 During the Course of Uncomplicated Pregnancies: A Prospective Study.
Tskitishvili, Ekaterine; Sharentuya, Namuxila; Tsubouchi, Hiroaki et al.
2010In American Journal of Reproductive Immunology, 64 (3), p. 218-24
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This is an electronic version (Author’s preprint) of the article published in American Journal of Reproductive Immunology, 2010 Sept 64(3):218-24 The original published version is available at:http://onlinelibrary.wiley.com/doi/10.1111/j.1600-0897.2010.00859.x/pdf
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Keywords :
Maternal blood,; plasma RCAS1 mRNA; serum
Abstract :
[en] Citation Tskitishvili E, Sharentuya N, Tsubouchi H, Kinugasa-Taniguchi Y, Kanagawa T, Shimoya K, Tomimatsu T, Kimura T. Maternal blood serum and plasma human tumor-associated antigen RCAS1 during the course of uncomplicated pregnancies: a prospective study. Am J Reprod Immunol 2010; 64: 218-224 Problem We aimed to investigate the expression of the tumor-associated RCAS1 protein in maternal blood of uncomplicated pregnancies. Method of study Maternal blood was obtained from women with uncomplicated pregnancies (N = 43) at 11-13, 20-22, 32-34, 37-38 weeks of gestation, and immediately after delivery. Serum RCAS1 concentration was studied by ELISA, and plasma mRNA was subjected to real-time (RT)-PCR. Results Serum RCAS1 protein concentration was significantly up-regulated at 11-13 and 20-22 weeks than that at 32-34 weeks and after delivery. RCAS1 mRNA level was significantly increased at 11-13 weeks than that at 37-38 weeks. A significant positive correlation was defined between RCAS1 serum concentration at 11-13 weeks and gestational age at delivery and that between plasma RCAS1 mRNA levels at 37-38 weeks and umbilical cord blood base excess. A significant negative correlation was found between RCAS1 serum concentration at 37-38 weeks and umbilical cord blood pH at delivery. Conclusions RCAS1 protein might have importance in the development of uncomplicated pregnancies and for the prediction of pregnancy outcome.
Disciplines :
Reproductive medicine (gynecology, andrology, obstetrics)
Author, co-author :
Tskitishvili, Ekaterine  ;  Université de Liège - ULiège > Département des sciences cliniques > Labo de biologie des tumeurs et du développement > Osaka University Graduate School of Medicine, Department of Obstetrics and Gynecology
Sharentuya, Namuxila;  Osaka University Graduate School of Medicine > Department of Obstetrics and Gynecology
Tsubouchi, Hiroaki;  Osaka University Graduate School of Medicine > Department of Obstetrics and Gynecology
Kinugasa-Taniguchi, Yukiko;  Osaka University Graduate School of Medicine > Department of Obstetrics and Gynecology
Kanagawa, Takeshi;  Osaka University Graduate School of Medicine > Department of Obstetrics and Gynecology
Shimoya, Koichiro;  Kawasaki Medical School > Department of Obstetrics and Gynecology
Tomimatsu, Takuji;  Osaka University Graduate School of Medicine > Department of Obstetrics and Gynecology
Kimura, Tadashi;  Osaka University Graduate School of Medicine > Department of Obstetrics and Gynecology
Language :
English
Title :
Maternal Blood Serum and Plasma Human Tumor-Associated Antigen RCAS1 During the Course of Uncomplicated Pregnancies: A Prospective Study.
Publication date :
2010
Journal title :
American Journal of Reproductive Immunology
ISSN :
1046-7408
eISSN :
1600-0897
Publisher :
Blackwell, Oxford, United Kingdom
Volume :
64
Issue :
3
Pages :
218-24
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
(c) 2010 John Wiley & Sons A/S.
Available on ORBi :
since 10 November 2010

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