Cytotoxic triterpenoid saponins from the roots of Cephalaria gigantea

[en] Three new oleanane-type saponins, giganteosides L (1)(I), M (2) and N (3) along with eight known ones were isolated from the roots of Cephalaria gigantea. Their structures were established as 3-O-[-D-galactopyranosyl-(12)--D-glucuronopyranosyl]-28-O-[-D-glucopyranosyl-(16)--D-glucopyranosyl]-oleanolic acid, 3-O-[-D-galactopyranosyl-(12)--D-glucuronopyranosyl]-28-O-[-D-glucopyranosyl-(16)--D-glucopyranosyl]-hederagenin, 3-O-[-L-rhamnopyranosyl-(12)--D-glucuronopyranosyl]-28-O-[-D-glucopyranosyl-(16)--D-glucopyranosyl]-hederagenin, resp., by means of spectroscopic methods (1D and 2D NMR, HR-ESI-MS). Cytotoxic activity of monodesmosides was investigated in vitro using three cancer cell lines, namely, human non pigmented melanoma MEL-5 and human leukemia HL-60. Giganteosides D (4) and E (5) showed antiproliferative effect on human cell lines with IC50 values in the range 3.15-7.5 M.

Disciplines :

Anatomy (cytology, histology, embryology...) & physiology

Author, co-author :

Tabatadze, Nino

Elias, Riad

Faure, Robert

Gerkens, Pascal

De Pauw-Gillet, Marie-Claire ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Histologie - Cytologie - Département des sciences biomédicales et précliniques

Kemertelidze

Chea, Aun

Ollivier, Evelyne

Language :

English

Title :

Cytotoxic triterpenoid saponins from the roots of Cephalaria gigantea

Publication date :

January 2007

Journal title :

Chemical and Pharmaceutical Bulletin

ISSN :

0009-2363

eISSN :

1347-5223

Publisher :

Pharmaceutical Society of Japan, Japan

Volume :

Issue :

Pages :

102-105

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 30 September 2010

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