Reference : New data on the intraindividual variation of cystatin C.
Scientific journals : Article
Human health sciences : Laboratory medicine & medical technology
Human health sciences : Urology & nephrology
New data on the intraindividual variation of cystatin C.
Delanaye, Pierre mailto [Centre Hospitalier Universitaire de Liège - CHU > > Néphrologie >]
Cavalier, Etienne mailto [Centre Hospitalier Universitaire de Liège - CHU > > Chimie médicale >]
Depas, Gisèle [Centre Hospitalier Universitaire de Liège - CHU > > Médecine nucléaire >]
Chapelle, Jean-Paul [Centre Hospitalier Universitaire de Liège - CHU > > Chimie médicale >]
Krzesinski, Jean-Marie mailto [Centre Hospitalier Universitaire de Liège - CHU > > Néphrologie >]
Nephron. Clinical Practice
Yes (verified by ORBi)
[en] Adult ; Analysis of Variance ; Biological Markers/blood ; Creatinine/blood ; Cystatin C ; Cystatins/blood ; Female ; Glomerular Filtration Rate ; Humans ; Immunoassay ; Iohexol/diagnostic use ; Kidney Diseases/diagnosis/physiopathology ; Kidney Function Tests/methods ; Male ; Middle Aged ; Nephelometry and Turbidimetry/methods ; Reference Values ; Reproducibility of Results
[en] BACKGROUND: Cystatin C is a new interesting marker of glomerular filtration rate (GFR). However, data regarding its biological variance are scarce and conflicting. The ability of cystatin C to longitudinally follow renal function in patients therefore remains questionable. METHODS: 12 healthy subjects (6 men and 6 women) were included in the final statistical analysis. Serum creatinine, plasma cystatin C and GFR were measured twice after a 1-week interval on the same day, at the same time, and under the same preanalytical and analytical conditions. GFR was measured with an iohexol method. Serum creatinine was measured with a compensated Jaffe and an enzymatic method. Plasma cystatin C was measured by a particle-enhanced immunonephelometric method. Analytical (CV(A)) and within-subject (CV(I)) variances were classically calculated. RESULTS: CV(A) for creatinine (Jaffe and enzymatic methods) and cystatin C was 2.5, 0.97 and 1.29%, respectively. CV(I) was 5.8, 5 and 4.5% for the Jaffe creatinine, enzymatic creatinine and cystatin C determinations, respectively. CONCLUSION: Our study confirms that intraindividual variation of cystatin C and creatinine are similar. Therefore, from a biological point of view, cystatin C seems as accurate as creatinine for the longitudinal follow-up of renal function in daily clinical practice.
Copyright 2008 S. Karger AG, Basel.

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