[en] This review covers the general roles of members of the cysteine protease family of caspases in the process of apoptosis (programmed cell death) looking at their participation in both the "extrinsic" cell death receptor and the "intrinsic" mitochondrial cell death pathways. It defines the difference between initiator and effector caspases and shows the progression of caspase activations that ends up in the apoptotic cell death and elimination of a damaged cell. The review then presents what is currently know about the participation of caspases in the programmed cell death of inner ear sensory cells during the process of normal development and maturation of the inner ear and their importance in this process as illustrated by the results of caspase-3 gene knockout experiments. The participation of specific caspases and the sequence of their activation in the elimination (apoptosis) of damaged sensory cells from adult inner ears after an injury that generates oxidative stress are reviewed. Both the possibility and the potential efficacy of caspase inhibition with a broad-spectrum pancaspase inhibitor as an interventional therapy to treat and rescue oxidative stress-damaged inner ear sensory cells from apoptosis are presented and discussed.
Disciplines :
Oto-rhino-laryngologie Neurologie
Auteur, co-auteur :
Van De Water, T. R.
Lallemend, François
Eshraghi, A. A.
Ahsan, S.
He, J.
Guzman, J.
Polak, M.
Malgrange, Brigitte ; Université de Liège - ULiège > CNCM/ Centre fac. de rech. en neurobiologie cell. et moléc.
Lefèbvre, Philippe ; Université de Liège - ULiège > Département des sciences cliniques > Oto-rhino-laryngologie et audiophonologie
Staecker, H.
Balkany, T. J.
Langue du document :
Anglais
Titre :
Caspases, the enemy within, and their role in oxidative stress-induced apoptosis of inner ear sensory cells
Date de publication/diffusion :
juillet 2004
Titre du périodique :
Otology and Neurotology
ISSN :
1531-7129
eISSN :
1537-4505
Maison d'édition :
Lippincott Williams & Wilkins, Philadelphia, Etats-Unis - Pennsylvanie
Vaux DL, Strasser A. The molecular biology of apoptosis. Proc Natl Acad Sci U S A 1996;93:2239-44.
Budihardjo I, Oliver H, Lutter M, et al. Biochemical pathways of caspase activation during apoptosis. Ann Rev Cell Dev Biol 1999;15:269-90.
Fisher U, Jaenicke RU, Schulze-Osthoff K. Many cuts to ruin: a comprehensive update of caspase substrates. Cell Death Differ 2003;10:76-100.
Slee EA, Adrain C, Martin SJ, et al. Executioner caspase-3, -6, and -7 perform distinct, non-redundant roles during the demolition phase of apoptosis. J Biol Chem 2001;276:7320-6.
Cao G, Luo Y, Nagayama T, et al. Cloning and characterization of rat caspase-9: implications for a role in mediating caspase-3 activation and hippocampal cell death after transient cerebral ischemia. J Cereb Blood Flow Metab 2002;22:534-46.
Renatus M, Stennicke HR, Scott FL, et al. Dimer formation drives the activation of the cell death protease caspase 9. Proc Natl Acad Sci U S A 2001;98:14250-5.
Lesuisse C, Martin LJ. Immature and mature cortical neurons engage different apoptotic mechanisms involving caspase-3 and the mitogen-activated protein kinase pathway. J Cereb Blood Flow Metab 2002;22:935-50.
Cain K, Brown DG, Langlais C, et al. Caspase activation involves the formation of the aposome, a large (approximately 700 kDa) caspase-activating complex. J Biol Chem 1999;274:22686-92.
Deshmukh M, Du C, Wang X, et al. Exogenous SMAC induces competence and permits caspase activation in sympathetic neurons. J Neurosci 2002;22:8018-27.
Maier JK, Lahoua Z, Gendron NH, et al. The neuronal apoptosis inhibitory protein is a direct inhibitor of caspases 3 and 7. J Neurosci 2002;22:2035-43.
Keane RW, Kraydieh S, Lotocki G, et al. Apoptotic and antiapoptotic mechanisms after traumatic brain injury. J Cerebral Blood Flow Metab 2001;21:1189-98.
Fekete DM, Hamburger SA, Waring MT, et al. Involvement of programmed cell death in morphogenesis of the vertebrate inner ear. Development 1997;124:2451-61.
Takahashi K, Kamiya K, Urase K, et al. Caspase-3-deficiency induces hyperplasia of supporting cells and degeneration of sensory cells resulting in the hearing loss. Brain Res 2001;894:359-67.
Morishita H, Makishima T, Kaneko C, et al. Deafness due to degeneration of cochlear neurons in caspase-3-deficient mice. Biochem Biophys Res Commun 2001;284:142-9.
Frago LM, Canon S, de la Rosa EJ, et al. Programmed cell death in the developing inner ear is balanced by nerve growth factor and insulin-like growth factor I. J Cell Sci 2003;116:475-86.
Liu W, Staecker H, Stupak H, et al. Caspase inhibitors prevent cisplatin-induced apoptosis of auditory sensory cells. Neuroreport 1998;9:2609-14.
Forge A, Li L. Apoptotic death of hair cells in mammalian vestibular sensory epithelia. Hear Res 2000;139:97-115.
Matsui JI, Ogilvie JM, Warchol ME, et al. Inhibition of caspases prevents ototoxic and ongoing hair cell death. J Neurosci 2002;22:1218-27.
Cheng AG, Cunningham LL, Rubel EW, et al. Hair cell death in the avian basilar papilla: characterization of the in vitro model and caspase activation. J Assoc Res Otolaryngol 2003;4:91-105.
Cunningham LL, Cheng AG, Rubel EW, et al. Caspase activation in hair cells of the mouse utricle exposed to neomycin. J Neurosci 2002;22:8532-40.
Watanabe K, Jinnouchi K, Hess A, et al. Detection of apoptotic change in the lipopolysaccharide (LPS)-treated cochlea of guinea pigs. Hear Res 2001;158:116-22.
Hu BH, Henderson D, Nicotera TM, et al. Involvement of apoptosis in progression of cochlear lesion following exposure to intense noise. Hear Res 2002;166:62-71.
Nicotera TM, Hu BH, Henderson D. The caspase pathway in noise-induced apoptosis of the chinchilla cochlea. J Assoc Res Otolaryngol 2003;4:466-77.
Alam SA, Oshima T, Suzuki M, et al. The expression of apoptosis-related proteins in the aged cochlea of Mongolian gerbils. Laryngoscope 2001;111:528-34.
Iwata A, Harlan JM, Vedder NB, et al. The caspase inhibitor z-VAD is more effective than CD18 adhesion blockade in reducing muscle ischemia-reperfusion injury: implication for clinical trials. Blood 2002;100:2077-80.
Schulz JB, Weller M, Moskowitz MA, et al. Caspases as treatment targets in stroke and neurodegenerative diseases. Ann Neurol 1999;45:421-9.
Seidman MD, Van De Water TR. Pharmacologic manipulation of the labyrinth with novel and traditional agents delivered to the inner ear. Ear Nose Throat J 2003;82:276-300.
Lefehvre PP, Malgrange B, Lallemend F, et al. Mechanisms of cell death in the injured auditory system: otoprotective strategies. Audiol Neurootol 2002;7:165-70.
