Experimental Acute Traumatic Injury of the Adult Rat Spinal Cord by a Subdural Inflatable Balloon: Methodology, Behavioral Analysis, and Histopathology
Martin, Didier; Schoenen, Jean; Delree, P.et al.
1992 • In Journal of Neuroscience Research, 32 (4), p. 539-50
[en] We describe an experimental model to produce closed traumatic injuries to the spinal cord of adult rats. This model uses an inflatable balloon that is introduced in the dorsal subdural space and moved to a location rostral to the laminectomy site. The spinal cord trauma can be graded by varying either the duration of compression or the volume of saline used to inflate the balloon. The locomotor deficit of animals with various degrees of injury has been assessed at increasing delays after trauma. The parameters generating transient or definitive deficits of varying intensity were defined. Some injured animals underwent nuclear magnetic resonance imaging. Detailed histopathological studies demonstrated that the extent of the spinal lesion was significantly correlated with the physical parameters of compression and with the severity of the behavioral deficit.
Disciplines :
Surgery
Author, co-author :
Martin, Didier ; Université de Liège - ULiège > Département des sciences cliniques > Neurochirurgie
Schoenen, Jean ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Neuro-anatomie
Delree, P.
Gilson, Valérie ; Université de Liège - ULiège > Didactique professionnelle et formation des enseignants
Rogister, Bernard ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biochimie et physiologie générales, et biochimie humaine
Leprince, Pierre ; Université de Liège - ULiège > CNCM/ Centre fac. de rech. en neurobiologie cell. et moléc.
Stevenaert, Achille ; Université de Liège - ULiège > Services généraux (Faculté de médecine) > Relations académiques et scientifiques (Médecine)
Moonen, Gustave ; Université de Liège - ULiège > Département des sciences cliniques > Neurologie - Doyen de la Faculté de Médecine
Language :
English
Title :
Experimental Acute Traumatic Injury of the Adult Rat Spinal Cord by a Subdural Inflatable Balloon: Methodology, Behavioral Analysis, and Histopathology
Publication date :
August 1992
Journal title :
Journal of Neuroscience Research
ISSN :
0360-4012
eISSN :
1097-4547
Publisher :
John Wiley & Sons, Hoboken, United States - New York
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