Syngeneic Grafting of Adult Rat Drg-Derived Schwann Cells to the Injured Spinal Cord

[en] A subdural inflatable micro-balloon was used to induce closed traumatic contusion to adult rat spinal cord. This spinal cord injury model was associated with reproducible and graded neurological deficits and histopathological alterations. At various delays after injury, transplantations of syngeneic adult cultured dorsal root ganglion-derived Schwann cells were performed into the spinal cord lesion. The transplants were well integrated and reduced the microcystic posttraumatic cavitation as well as the gliosis. Schwann cells transplants were invaded by numerous regenerating neurites most of which, based upon their neurotransmitter contents, seem to originate from the dorsal root ganglion.

Disciplines :

Surgery

Author, co-author :

Martin, Didier ; Université de Liège - ULiège > Département des sciences cliniques > Neurochirurgie

Schoenen, Jean ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Neuro-anatomie

Delree, P.

Rigo, Jean-Michel

Rogister, Bernard ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biochimie et physiologie générales, et biochimie humaine

Leprince, Pierre ; Université de Liège - ULiège > CNCM/ Centre fac. de rech. en neurobiologie cell. et moléc.

Moonen, Gustave ; Université de Liège - ULiège > Neurologie Sart Tilman

Language :

English

Title :

Syngeneic Grafting of Adult Rat Drg-Derived Schwann Cells to the Injured Spinal Cord

Publication date :

1993

Journal title :

Brain Research Bulletin

ISSN :

0361-9230

eISSN :

1873-2747

Publisher :

Elsevier, Netherlands

Volume :

Issue :

3-4

Pages :

507-14

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 27 February 2009

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Bibliography

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