Plasticity of Developing and Adult Dorsal Root Ganglion Neurons as Revealed in Vitro

[en] We review recent data on the plasticity of dorsal root ganglion (DRG) neurons as revealed during cultivation in vitro. Some experiments on cultured developing DRG neurons and on adult DRG neurons in vivo are also mentioned. Cultured developing and adult DRG neurons can be switched from an apolar to a multipolar phenotype by fetal calf serum or fibronectin. The effect is concentration dependent and occurs through an early modification of cell-substratum interaction. Adult DRG neurons synthesize and release within hours after injury TGF beta-1, which is a mitogen and a differentiation factor for Schwann cells. Finally, adult DRG neurons express in vitro neurotransmitters that are not expressed in vivo. This neurotransmitter plasticity can be modulated in vitro by some growth factors and in vivo by distal or proximal axotomy.

Disciplines :

Surgery

Author, co-author :

Delree, P.

Ribbens, Clio ; Centre Hospitalier Universitaire de Liège - CHU > Rhumatologie

Martin, Didier ; Université de Liège - ULiège > Département des sciences cliniques > Neurochirurgie

Rogister, Bernard ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biochimie et physiologie générales, et biochimie humaine

LEFEBVRE, Philippe

Rigo, Jean-Michel

Leprince, Pierre ; Université de Liège - ULiège > CNCM/ Centre fac. de rech. en neurobiologie cell. et moléc.

Schoenen, Jean ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Neuro-anatomie

Moonen, Gustave ; Université de Liège - ULiège > Neurologie Sart Tilman

Language :

English

Title :

Plasticity of Developing and Adult Dorsal Root Ganglion Neurons as Revealed in Vitro

Publication date :

1993

Journal title :

Brain Research Bulletin

ISSN :

0361-9230

eISSN :

1873-2747

Publisher :

Elsevier, Netherlands

Volume :

Issue :

3-4

Pages :

231-7

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 27 February 2009

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