[en] There is an increasing body of evidence that volatile anaesthetics protect myocardium against ischaemic insult by a mechanism termed 'anaesthetic preconditioning'. Anaesthetic preconditioning and ischaemic preconditioning share several common mechanisms of action. Since ischaemic preconditioning has been demonstrated in organs other than the heart, anaesthetic preconditioning might also apply in these organs and have significant clinical applications in surgical procedures carrying a high risk of ischaemia-reperfusion injury. After a brief review on myocardial preconditioning, experimental and clinical data on preconditioning in non-cardiac tissues will be presented. Potential benefits of anaesthetic preconditioning during non-cardiac surgery will be addressed.
Disciplines :
Anesthesia & intensive care
Author, co-author :
Minguet, Grégory ; Centre Hospitalier Universitaire de Liège - CHU > Anesthésie et réanimation
Joris, Jean ; Université de Liège - ULiège > Département des sciences cliniques > Anesthésie et réanimation
Lamy, Maurice ; Université de Liège - ULiège > Département des sciences cliniques > Anesthésie et réanimation
Language :
English
Title :
Preconditioning and protection against ischaemia-reperfusion in non-cardiac organs: a place for volatile anaesthetics?
Publication date :
September 2007
Journal title :
European Journal of Anaesthesiology
ISSN :
0265-0215
eISSN :
1365-2346
Publisher :
Cambridge University Press, Cambridge, United Kingdom
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