Reference : Myelome multiple et infection a VIH/SIDA : a propos de trois observations.
Scientific journals : Article
Human health sciences : Immunology & infectious disease
Myelome multiple et infection a VIH/SIDA : a propos de trois observations.
[en] Multiple myeloma and HIV infection: report of 3 cases
Elira Dokekias, A. [> > > >]
Moutschen, Michel mailto [Université de Liège - ULiège > Département des sciences cliniques > GIGA-R:Immunopath. - Maladies infect. et médec. inter. gén. >]
Purhuence, M. F. [> > > >]
Malanda, F. [> > > >]
Moyikoua, A. [> > > >]
Revue Médicale de Liège
Hopital de Baviere
Yes (verified by ORBi)
[en] Adult ; Antineoplastic Combined Chemotherapy Protocols/administration & dosage ; Cyclophosphamide/administration & dosage ; Female ; HIV Infections/complications ; Humans ; Immunoglobulin A/blood ; Immunoglobulin G/blood ; Melphalan/administration & dosage ; Middle Aged ; Multiple Myeloma/diagnosis/drug therapy/virology ; Prednisone/administration & dosage ; Vincristine/administration & dosage
[en] HIV infection rages at the endemic state in Sub Saharan African and especially in Congo Brazzaville. We report the observation of three female patients infected with HIV and developing multiple myeloma. The three patients were treated at the University hospital of Brazzaville between 2000 and 2002. In two cases multiple myeloma was discovered after the diagnosis of HIV infection. In the other case, the diagnosis of HIV infection was posterior to the occurrence of multiple myeloma. HIV infection was symptomatic in two cases who received consequently antiviral treatment. Multiple myeloma was diagnosed at an advanced stage in the three cases. The paraprotein was an IgG in two cases and an IgA in the other one. The CD4 counts before treatment were around 200/mm3 in two cases and within normal limits in the third case. Viral load was not measured. VMCP and VAMCP regimens were administered without major complications and under anti-infectious prophylaxis. The follow-up is still insufficient to assess the medium-term evolution and to determine the prognosis of multiple myeloma. The description of these three cases confirms the involvement of HIV in B cell lymphoma genesis.

File(s) associated to this reference

Fulltext file(s):

Open access
Myelome multiple et infection a VIH-SIDA, a propos de 3 observations.pdfPublisher postprint429.71 kBView/Open

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.