Article (Scientific journals)
Theoretical study of the C-N bond breakage catalyzed by the serine peptidases
Dive, Georges; Peeters, Daniel; Leroy, Georges et al.
1984In Journal of Molecular Structure: Theochem, 16, p. 117-126
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Abstract :
[en] The conditions of C---N bond breakage by the serine peptidases have been analysed. A two-way table has been generated where either formamide or protonated formamide serves as minimal model of the scissile C---N bond and where either methanol or the couple CH3O− H+ serves as minimal model of the attacking nucleophile. An addition-elimination reaction is proposed which links the enzyme acylation and deacylation steps.
Disciplines :
Microbiology
Chemistry
Author, co-author :
Dive, Georges ;  Université de Liège - ULiège > Institut de Chimie > Laboratoire de Chimie Pharmaceutique > Service de Microbiologie
Peeters, Daniel;  Université Catholique de Louvain - UCL > Laboratoire de Chimie quantique
Leroy, Georges;  Université Catholique de Louvain - UCL > Laboratoire de Chimie quantique
Ghuysen, Jean-Marie ;  Université de Liège - ULiège > Institut de Chimie > Laboratoire de Chimie Pharmaceutique > Service de Microbiologie
Language :
English
Title :
Theoretical study of the C-N bond breakage catalyzed by the serine peptidases
Publication date :
February 1984
Journal title :
Journal of Molecular Structure: Theochem
ISSN :
0166-1280
Publisher :
Elsevier Science, Amsterdam, Netherlands
Volume :
16
Pages :
117-126
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
Available on ORBi :
since 03 September 2010

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