Article (Scientific journals)
Mathematical Modeling in Wound Healing, Bone Regeneration and Tissue Engineering
Geris, Liesbet; Gerisch, Alf; Schugart, Richard C.
2010In Acta Biotheoretica, 58 (4), p. 355-367
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Keywords :
Mathematical modeling; Wound healing; Bone regeneration; Tissue engineering
Abstract :
[en] The processes of wound healing and bone regeneration and problems in tissue engineering have been an active area for mathematical modeling in the last decade. Here we review a selection of recent models which aim at deriving strategies for improved healing. In wound healing, the models have particularly focused on the inflammatory response in order to improve the healing of chronic wound. For bone regeneration, the mathematical models have been applied to design optimal and new treatment strategies for normal and specific cases of impaired fracture healing. For the field of tissue engineering, we focus on mathematical models that analyze the interplay between cells and their biochemical cues within the scaffold to ensure optimal nutrient transport and maximal tissue production. Finally, we briefly comment on numerical issues arising from simulations of these mathematical models.
Disciplines :
Anatomy (cytology, histology, embryology...) & physiology
Computer science
Microbiology
Author, co-author :
Geris, Liesbet  ;  Université de Liège - ULiège > Département d'aérospatiale et mécanique > Génie biomécanique
Gerisch, Alf;  Institut fur Mathematik, Martin-Luther-Universitat, Halle-Wittenberg, 06099 Halle (Saale), Germany
Schugart, Richard C.;  Department of Mathematics and Computer Science, Western Kentucky University, 1906 College Heights Blvd, #11078, Bowling Green, KY 42101-1078, USA
Language :
English
Title :
Mathematical Modeling in Wound Healing, Bone Regeneration and Tissue Engineering
Publication date :
2010
Journal title :
Acta Biotheoretica
ISSN :
0001-5342
eISSN :
1572-8358
Publisher :
Springer, Dordrecht, Netherlands
Volume :
58
Issue :
4
Pages :
355-367
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 26 August 2010

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