Article (Scientific journals)
Modulation of the HSV-TK/ganciclovir bystander effect by n-butyrate in glioblastoma: correlation with gap-junction intercellular communication.
Robe, Pierre; Jolois, Olivier; Nguyen Khac, Minh-Tuan et al.
2004In International Journal of Oncology, 25 (1), p. 187-92
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Keywords :
Butyrates/pharmacology; Bystander Effect/drug effects/physiology; Cell Communication/physiology; Cell Line, Tumor; Connexin 43/analysis; Gap Junctions/physiology; Glioblastoma; Humans; Simplexvirus/enzymology; Thymidine Kinase/pharmacology
Abstract :
[en] The efficacy of HSV-TK/ganciclovir gene therapy largely relies on the bystander effect, i.e. the ability of transfected cells to kill the adjacent, untrasfected cells. This mechanism itself depends chiefly on the transfer via gap junctions of phosphorylated ganciclovir between cells, and is often deficient in glioblastomas. In this report, we demonstrate that n-butyrate markedly enhances the gap junction intercellular communication of GJIC-deficient glioma cells, and significantly increases the bystander effect in such cells. This effect of n-butyrate appears to be independent from its HDAC inhibitory effect, since trichostatin A does not reproduce it.
Disciplines :
Neurology
Author, co-author :
Robe, Pierre ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > GIGA-R : Génétique générale et humaine - Département des sciences biomédicales et précliniques
Jolois, Olivier ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Histologie humaine
Nguyen Khac, Minh-Tuan ;  Université de Liège - ULiège > Neurochirurgie
Princen
Malgrange, Brigitte  ;  Université de Liège - ULiège > GIGA - Neurosciences - Neurologie
Merville, Marie-Paule ;  Université de Liège - ULiège > Département de pharmacie > Chimie médicale
Bours, Vincent ;  Centre Hospitalier Universitaire de Liège - CHU > Génétique
Language :
English
Title :
Modulation of the HSV-TK/ganciclovir bystander effect by n-butyrate in glioblastoma: correlation with gap-junction intercellular communication.
Publication date :
2004
Journal title :
International Journal of Oncology
ISSN :
1019-6439
eISSN :
1791-2423
Publisher :
DA Spandidos, Athens, Greece
Volume :
25
Issue :
1
Pages :
187-92
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 26 August 2010

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