Reference : Modulation of the HSV-TK/ganciclovir bystander effect by n-butyrate in glioblastoma: ...
Scientific journals : Article
Human health sciences : Neurology
http://hdl.handle.net/2268/70324
Modulation of the HSV-TK/ganciclovir bystander effect by n-butyrate in glioblastoma: correlation with gap-junction intercellular communication.
English
Robe, Pierre mailto [Université de Liège - ULiège > Département des sciences biomédicales et précliniques > GIGA-R : Génétique générale et humaine - Département des sciences biomédicales et précliniques >]
Jolois, Olivier mailto [Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Histologie humaine >]
Nguyen Khac, Minh-Tuan [Université de Liège - ULiège > > Neurochirurgie >]
Princen [ > > ]
Malgrange, Brigitte mailto [Université de Liège - ULiège > > GIGA - Neurosciences - Neurologie >]
Merville, Marie-Paule mailto [Université de Liège - ULiège > Département de pharmacie > Chimie médicale >]
Bours, Vincent mailto [Centre Hospitalier Universitaire de Liège - CHU > > Génétique >]
2004
International Journal of Oncology
DA Spandidos
25
1
187-92
Yes (verified by ORBi)
International
1019-6439
1791-2423
Athens
Greece
[en] Butyrates/pharmacology ; Bystander Effect/drug effects/physiology ; Cell Communication/physiology ; Cell Line, Tumor ; Connexin 43/analysis ; Gap Junctions/physiology ; Glioblastoma ; Humans ; Simplexvirus/enzymology ; Thymidine Kinase/pharmacology
[en] The efficacy of HSV-TK/ganciclovir gene therapy largely relies on the bystander effect, i.e. the ability of transfected cells to kill the adjacent, untrasfected cells. This mechanism itself depends chiefly on the transfer via gap junctions of phosphorylated ganciclovir between cells, and is often deficient in glioblastomas. In this report, we demonstrate that n-butyrate markedly enhances the gap junction intercellular communication of GJIC-deficient glioma cells, and significantly increases the bystander effect in such cells. This effect of n-butyrate appears to be independent from its HDAC inhibitory effect, since trichostatin A does not reproduce it.
http://hdl.handle.net/2268/70324

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