The effect of micro-motion on the tissue response around immediately loaded roughened titanium implants in the rabbit.

Animals; Dental Alloys; Dental Implantation, Endosseous; Dental Implants; Dental Stress Analysis; Diffusion Chambers, Culture; Female; Histological Techniques; Implants, Experimental; Motion; Osseointegration/physiology; Rabbits; Regression Analysis; Specific Pathogen-Free Organisms; Surface Properties; Tibia; Titanium

Abstract :

[en] Initial osteogenesis at the implant interface is, to a great extent, determined by the implant surface characteristics and the interfacial loading conditions. The present study investigated the effect of various degrees of relative movement on the tissue differentiation around a roughened screw-shaped immediately loaded implant. Repeated-sampling bone chambers were installed in the tibia of 10 rabbits. In each of the chambers, three experiments were performed by inducing 0 (control), 30, and 90 microm implant displacement for 9 wk. A linear mixed model and a logistic mixed model with alpha = 5% determined statistical significance. Tissue filling of the bone chamber was similar for the three test conditions. The bone area fraction was significantly higher for 90 microm implant displacement compared with no displacement. A significantly higher fraction of bone trabeculae was found for 30 and 90 microm implant displacement compared with the unloaded situation. The incidence of osteoid-to-implant and bone-to-implant contact was significantly higher for 90 microm implant displacement compared with 30 and 0 microm implant displacement. Significantly more osteoid in contact with the implant was found for the loaded conditions compared with no loading. Well-controlled micro-motion positively influenced bone formation at the interface of a roughened implant. An improved bone reaction was detected with increasing micro-motion.

Disciplines :

Biochemistry, biophysics & molecular biology
Microbiology

Author, co-author :

Vandamme, Katleen; Department of Prosthetic Dentistry/BIOMAT Research Group

Naert, Ignace; Department of Prosthetic Dentistry/BIOMAT Research Group

Geris, Liesbet ; Division of Biomechanics and Engineering Design

Vander Sloten, Jozef; Division of Biomechanics and Engineering Design

Puers, Robert; Department of Electrical Engineering – ESAT-MICAS, K.U. Leuven, Leuven, Belgium

Duyck, Joke; Department of Prosthetic Dentistry/BIOMAT Research Group

Language :

English

Title :

The effect of micro-motion on the tissue response around immediately loaded roughened titanium implants in the rabbit.

Publication date :

2007

Journal title :

European Journal of Oral Sciences

ISSN :

0909-8836

eISSN :

1600-0722

Publisher :

Blackwell Publishing

Volume :

115

Issue :

Pages :

21-9

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 26 August 2010

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Bibliography

WENNERBERG A. On surface roughness and implant incorporation. Thesis. Göteborg, Sweden: Göteborg University, 1996.
ABRAHAMSSON I, BERGLUNDH T, LINDER E, LANG NP, LINDHE J. Early bone formation adjacent to rough and turned endosseous implant surfaces. An experimental study in the dog. Clin Oral Implants Res 2004; 15: 381-392.
BOTTICELLI D, BERGLUNDH T, PERSSON LG, LINDHE J. Bone regeneration at implants with turned or rough surfaces in self-contained defects. An experimental study in the dog. J Clin Periodontol 2005; 32: 448-455.
AKIMOTO K, BECKER W, PERSSON R, BAKER DA, ROHRER MD, O'NEAL RB. Evaluation of titanium implants placed into simulated extraction sockets: a study in dogs. Int J Oral Maxillofac Implants 1999; 14: 351-360.
BERGLUNDH T, ABRAHAMSSON I, LANG NP, LINDHE J. De novo alveolar bone formation adjacent to endosseous implants. Clin Oral Implants Res 2003; 14: 251-262.
SLAETS E, CARMELIET G, NAERT I, DUYCK J. Early cellular responses in cortical bone healing around unloaded titanium implants: an animal study. J Periodontol 2006; 77: 1015-1024.
STEIGENGA JT, AL-SHAMMARI KF, NOCITI FH, MISCH CE, WANG HL. Dental implant design and its relationship to long-term implant success. Implant Dent 2003; 12: 306-317.
VANDAMME K, NAERT I, GERIS L, VANDER SLOTEN J, PUERS R, DUYCK J. The influence of controlled immediate loading and implant design on peri-implant bone formation. J Clin Periodontol 2007; 34: in press.
BOWERS KT, KELLER JC, RANDOLPH BA, WICK DG, MICHAELS CM. Optimization of surface micromorphology for enhanced osteoblast responses in vitro. Int J Oral Maxillofac Implants 1992; 7: 302-310.
MARTIN JY, SCHWARTZ Z, HUMMERT TW, SCHRAUB DM, SIMPSON J, LANKFORD J Jr, DEAN DD, COCHRAN DL, BOYAN BD. Effect of titanium surface roughness on proliferation, differentiation, and protein synthesis of human osteoblast-like cells (MG63). J Biomed Mater Res 1995; 29: 389-401.
COOPER LF, MASUDA T, WHITSON SW, YLIHEIKKILA P, FELTON DA. Formation of mineralizing osteoblast cultures on machined, titanium oxide grit-blasted, and plasma-sprayed titanium surfaces. Int J Oral Maxillofac Implants 1999; 14: 37-47.
SCHWARTZ Z, LOHMANN CH, OEFINGER J, BONEWALD LF, DEAN DD, BOYAN BD. Implant surface characteristics modulate differentiation behavior of cells in the osteoblastic lineage. Adv Dent Res 1999; 13: 38-48.
SCHWARTZ Z, NASAZKY E, BOYAN BD. Surface microtopography regulates osteointegration: the role of implant surface microtopography in osteointegration. Alpha Omegan 2005; 98: 9-19.
BUSER D, BROGGINI N, WIELAND M, SCHENK RK, DENZER AJ, COCHRAN DL, HOFFMANN B, LUSSI A, STEINEMANN SG. Enhanced bone apposition to a chemically modified SLA titanium surface. J Dent Res 2004; 83: 529-533.
LOSSDORFER S, SCHWARTZ Z, WANG L, LOHMANN CH, TURNER JD, WIELAND M, COCHRAN DL, BOYAN BD. Microrough implant surface topographies increase osteogenesis by reducing osteoclast formation and activity. J Biomed Mater Res A 2004; 70: 361-369.
SAMMONS RL, LUMBIKANONDA N, GROSS M, CANTZLER P. Comparison of osteoblast spreading on microstructured dental implant surfaces and cell behaviour in an explant model of osseointegration. A scanning electron microscopic study. Clin Oral Implants Res 2005; 16: 657-666.
DAVIES JE. Mechanisms of endosseous integration. Int J Prosthodont 1998; 11: 391-401.
MATSUO M, NAKAMURA T, KISHI Y, TAKAHASHI K. Microvascular changes after placement of titanium implants: scanning electron microscopy observations of machined and titanium plasma-sprayed implants in dogs. J Periodontol 1999; 70: 1330-1338.
THOMAS KA, COOK SD. An evaluation of variables influencing implant fixation by direct bone apposition. J Biomed Mater Res 1985; 19: 875-901.
BUSER D, SCHENK RK, STEINEMANN S, FIORELLINI JP, FOX CH, STICH H. Influence of surface characteristics on bone integration of titanium implants. A histomorphometric study in miniature pigs. J Biomed Mater Res 1991; 25: 889-902.
WENNERBERG A, ALBREKTSSON T, ANDERSSON B, KROL JJ. A histomorphometric and removal torque study of screw-shaped titanium implants with three different surface topographies. Clin Oral Implants Res 1995; 6: 24-30.
NOVAES AB JR, PAPALEXIOU V, GRISI MF, SOUZA SS, TABA M JR, KAJIWARA JK. Influence of implant microstructure on the osseointegration of immediate implants placed in periodontally infected sites. A histomorphometric study in dogs. Clin Oral Implants Res 2004; 15: 34-43.
VEIS AA, TRISI P, PAPADIMITRIOU S, TSIRLIS AT, PARISSIS NA, DESIRIS AK, LAZZARA RJ. Osseointegration of Osseotite and machined titanium implants in autogenous bone graft. A histologic and histomorphometric study in dogs. Clin Oral Implants Res 2004; 15: 54-61.
COCHRAN DL, SCHENK RK, LUSSI A, HIGGINBOTTOM FL, BUSER D. Bone response to unloaded and loaded titanium implants with a sandblasted and acid-etched surface: a histometric study in the canine mandible. J Biomed Mater Res 1998; 40: 1-11.
COCHRAN DL. A comparison of endosseous dental implant surfaces. J Periodontol 1999; 70: 1523-1539.
IVANOFF CJ, HALLGREN C, WIDMARK G, SENNERBY L, WENNERBERG A. Histologic evaluation of the bone integration of TiO(2) blasted and turned titanium microimplants in humans. Clin Oral Implants Res 2001; 12: 128-134.
IVANOFF CJ, WIDMARK G, JOHANSSON C, WENNERBERG A. Histologic evaluation of bone response to oxidized and turned titanium micro-implants in human jawbone. Int J Oral Maxillofac Implants 2003; 18: 341-348.
CARTER DR, BEAUPRÉ GS, GIORI NJ, HELMS J. Mechanobiology of skeletal regeneration. Clin Orthop Relat Res 1998; 355: 41S-55S.
ALBREKTSSON T, ERIKSSON AR, JACOBSSON M, KALEBO P, STRID KG, TJELLSTROM A. Bone repair in implant models: a review with emphasis on the harvest chamber for bone regeneration studies. Int J Oral Maxillofac Implants 1989; 4: 45-54.
ASPENBERG P, GOODMAN S, TOKSVIG-L ARSEN S, RYD L, ALBREKTSSON T. Intermittent micromotion inhibits bone in-growth. Titanium implants in rabbits. Acta Orthop Scand 1992; 63: 141-145.
DE ROOIJ PP, SIEBRECHT MA, TAGIL M, ASPENBERG P. The fate of mechanically induced cartilage in an unloaded environment. J Biomech 2001; 34: 961-966.
GOODMAN SB, SONG Y, DOSHI A, ASPENBERG P. Cessation of strain facilitates bone formation in the micromotion chamber implanted in the rabbit tibia. Biomaterials 1994; 15: 889-893.
GULDBERG RE, CALDWELL NJ, GUO XW, GOULET RW, HOLLISTER SJ, GOLDSTEIN SA. Mechanical stimulation of tissue repair in the hydraulic bone chamber. J Bone Miner Res 1997; 12: 1295-1302.
MOALLI MR, CALDWELL NJ, PATIL PV, GOLDSTEIN SA. An in vivo model for investigations of mechanical signal transduction in trabecular bone. J Bone Miner Res 2000; 15: 1346-1353.
TAGIL M, ASPENBERG P. Cartilage induction by controlled mechanical stimulation in vivo. J Orthop Res 1999; 17: 200-204.
SZMUKLER-MONCLER S, SALAMA H, REINGEWIRTZ Y, DUBRUILLE JH. Timing of loading and effect of micromotion on bone-dental implant interface: review of experimental literature. J Biomed Mater Res 1998; 43: 192-203.
CAMERON HU, PILLIAR RM, MACNAB I. The effect of movement on the bonding of porous metal to bone. J Biomed Mater Res 1973; 7: 301-311.
UHTHOFF HK. Mechanical factors influencing the holding power of screws in compact bone. J Bone Joint Surg Br 1973; 55: 633-639.
DUYCK J, VANDAMME K, GERIS L, VAN OOSTERWYCK H, DE COOMAN M, VANDER SLOTEN J, PUERS R, NAERT I. The influence of micro-motion on the tissue differentiation around immediately loaded cylindrical turned titanium implants. Arch Oral Biol 2006; 51: 1-9.
DUYCK J, DE COOMAN M, PUERS R, VAN OOSTERWYCK H, VANDER SLOTEN J, NAERT I. A repeated sampling bone chamber methodology for the evaluation of tissue differentiation and bone adaptation around titanium implants under controlled mechanical conditions. J Biomech 2004; 37: 1819-1822.
VANDAMME K, NAERT I, GERIS L, VANDER SLOTEN J, PUERS R, DUYCK J. Histodynamics of bone tissue formation around immediately loaded cylindrical implants in the rabbit. Clin Oral Implants Res 2007: in press.
BRANEMARK PI, ADELL R, BREINE U, HANSSON BO, LINDSTROM J, OHLSSON A. Intra-osseous anchorage of dental prostheses. Scand J Plast Reconstr Surg 1969; 3: 81-100.
GAPSKI R, WANG HL, MASCARENHAS P, LANG NP. Critical review of immediate implant loading. Clin Oral Implants Res 2003; 14: 515-527.
ROMANOS GE. Present status of immediate loading of oral implants. J Oral Implantol 2004; 30: 189-197.
SZMUKLER-MONCLER S, PERRIN D, AHOSSI V, MAGNIN G, BERNARD JP. Biological properties of acid etched titanium implants: effect of sandblasting on bone anchorage. J Biomed Mater Res B Appl Biomater 2004; 68: 149-159.
FRITTON JC, MYERS ER, WRIGHT TM, VAN DER MEULEN MC. Loading induces site-specific increases in mineral content assessed by microcomputed tomography of the mouse tibia. Bone 2005; 36: 1030-1038.
VAN DER MEULEN MC, MORGAN TG, YANG X, BALDINI TH, MYERS ER, WRIGHT TM, BOSTROM MP. Cancellous bone adaptation to in vivo loading in a rabbit model. Bone 2006; 38: 871-877.
PIATTELLI A, CORIGLIANO M, SCARANO A, COSTIGLIOLA G, PAOLANTONIO M. Immediate loading of titanium plasma-sprayed implants: an histologic analysis in monkeys. J Periodontol 1998; 69: 321-327.
NKENKE E, LEHNER B, WEINZIERL K, THAMS U, NEUGEBAUER J, STEVELING H, RADESPIEL-TROGER M, NEUKAM FW. Bone contact, growth, and density around immediately loaded implants in the mandible of mini pigs. Clin Oral Implants Res 2003; 14: 312-321.
MEYER U, JOOS U, MYTHILI J, STAMM T, HOHOFF A, FILLIES T, STRATMANN U, WIESMANN HP. Ultrastructural characterization of the implant/bone interface of immediately loaded dental implants. Biomaterials 2004; 25: 1959-1967.
ESPOSITO M, WORTHINGTON HV, THOMSEN P, COULTHARD P. Interventions for replacing missing teeth: different times for loading dental implants. Cochrane Database Syst Rev 2004: 3: CD003878.