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Oral calcitonin in the management of osteoarthritis: hope or fantasy ?

Reginster, Jean-Yves; Neuprez, Audrey; Hiligsmann, Mickaël et al.

2010 • In International Journal of Clinical Rheumatology, 5 (1), p. 53-58

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https://hdl.handle.net/2268/70119

DOI
10.2217/ijr.09.68

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Abstract :

[en] In the mid-1980s, calcitonin was used as a potential treatment for postmenopausal osteoporosis. However, after the results obtained in a pivotal study assessing the antifracture efficacy of the drug showed an absence of reduction in nonvertebral fractures, calcitonin has almost completely disappeared from the osteoporosis armomentarium. The development of a new ‘high-tech’ oral formulation of salmon calcitonin and the demonstration, in several in vitro and in vivo models of osteoarthritis, that this drug could exert beneficial effects on the chondrocytes and on the development of experimental osteoarthritis has generated some interest in this old molecule. However, at this stage, results from clinical trials remain inconclusive and caution should be exerted before considering oral calcitonin as a breakthrough in the management of osteoarthritis.

Disciplines :

General & internal medicine

Author, co-author :

Reginster, Jean-Yves ; Université de Liège - ULiège > Département des sciences de la santé publique > Santé publique, Epidémiologie et Economie de la santé

Neuprez, Audrey ; Université de Liège - ULiège > Département des sciences de la santé publique > Santé publique, Epidémiologie et Economie de la santé

Hiligsmann, Mickaël ; Université de Liège - ULiège > Département des sciences de la santé publique > Département des sciences de la santé publique

Bruyère, Olivier ; Université de Liège - ULiège > Département des sciences de la santé publique > Santé publique, Epidémiologie et Economie de la santé

Language :

English

Title :

Oral calcitonin in the management of osteoarthritis: hope or fantasy ?

Publication date :

February 2010

Journal title :

International Journal of Clinical Rheumatology

ISSN :

1758-4272

eISSN :

1758-4280

Publisher :

Future Medicine Ltd

Volume :

5

Issue :

1

Pages :

53-58

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 23 June 2011

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110 (7 by ULiège)

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3 (3 by ULiège)

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3

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2

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3

OpenAlex citations

3

Bibliography

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