Article (Scientific journals)
Pulmonary Ventilation, Mechanics, Gas Exchange and Haemodynamics in Calves Following Intratracheal Inoculation of Pasteurella Haemolytica
Linden, Annick; Desmecht, Daniel; Amory, Hélène et al.
1995In Zentralblatt für Veterinarmedizin. Reihe A, 42 (8), p. 531-544
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Keywords :
Pasteurella; experimental infection; Calves; pulmonary parameters
Abstract :
[en] A Pasteurella haemolytica A1 broth was injected intratracheally in eight calves and measurements of pulmonary function values (PFV) were made once before and hourly post inoculation (p.i.). Changes in PFVs, included increased respiratory rate and minute ventilation (up to 158% of baseline 2 h p.i.) and decreased tidal volume and lung dynamic compliance (up to 33% of baseline 3 h p.i.). Total pulmonary resistance was not affected. At and after 3 h p.i. there was a progressive impairement of gas exchange, as judged from arterial O2 tension which decreased up to 65% of baseline. In contrast, arterial CO2 tension was not affected. Pulmonary hypertension was observed during the 3 last h of the study and was attributable to an increased pulmonary vascular resistance. Severe neutropenia was observed at 3 h p.i. and post-mortem histological findings were consistent with an acute fibrinohemorragic bronchopneumonia. In conclusion, P. haemolytica airway challenge unequiovocally resulted in acute pneumonia, providing a reproducible pathophysiological model for investigations regarding new therapeutic strategies.
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Linden, Annick  ;  Université de Liège - ULiège > Département des maladies infectieuses et parasitaires > Santé et pathologies de la faune sauvage
Desmecht, Daniel ;  Université de Liège - ULiège > Département de morphologie et pathologie > Pathologie spéciale et autopsies
Amory, Hélène ;  Université de Liège - ULiège > Département clinique des animaux de compagnie et des équidés > Médecine interne des équidés
Daube, Georges  ;  Université de Liège - ULiège > Département de sciences des denrées alimentaires > Microbiologie des denrées alimentaires
Lecomte, S.
Lekeux, Pierre ;  Université de Liège - ULiège > Département de sciences fonctionnelles > Physiologie
Language :
English
Title :
Pulmonary Ventilation, Mechanics, Gas Exchange and Haemodynamics in Calves Following Intratracheal Inoculation of Pasteurella Haemolytica
Publication date :
1995
Journal title :
Zentralblatt für Veterinarmedizin. Reihe A
ISSN :
0514-7158
Publisher :
Verlag Paul Parey, Germany
Volume :
42
Issue :
8
Pages :
531-544
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 23 February 2009

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