Reference : Pulmonary Ventilation, Mechanics, Gas Exchange and Haemodynamics in Calves Following ...
Scientific journals : Article
Life sciences : Veterinary medicine & animal health
Pulmonary Ventilation, Mechanics, Gas Exchange and Haemodynamics in Calves Following Intratracheal Inoculation of Pasteurella Haemolytica
Linden, Annick mailto [Université de Liège - ULiège > Département des maladies infectieuses et parasitaires > Santé et pathologies de la faune sauvage >]
Desmecht, Daniel mailto [Université de Liège - ULiège > Département de morphologie et pathologie > Pathologie spéciale et autopsies >]
Amory, Hélène mailto [Université de Liège - ULiège > Département clinique des animaux de compagnie et des équidés > Médecine interne des équidés >]
Daube, Georges mailto [Université de Liège - ULiège > Département de sciences des denrées alimentaires > Microbiologie des denrées alimentaires >]
Lecomte, S. [> > > >]
Lekeux, Pierre mailto [Université de Liège - ULiège > Département de sciences fonctionnelles > Physiologie >]
Zentralblatt für Veterinarmedizin. Reihe A
Yes (verified by ORBi)
[en] Pasteurella ; experimental infection ; Calves ; pulmonary parameters
[en] A Pasteurella haemolytica A1 broth was injected intratracheally in eight calves and measurements of pulmonary function values (PFV) were made once before and hourly post inoculation (p.i.). Changes in PFVs, included increased respiratory rate and minute ventilation (up to 158% of baseline 2 h p.i.) and decreased tidal volume and lung dynamic compliance (up to 33% of baseline 3 h p.i.). Total pulmonary resistance was not affected. At and after 3 h p.i. there was a progressive impairement of gas exchange, as judged from arterial O2 tension which decreased up to 65% of baseline. In contrast, arterial CO2 tension was not affected. Pulmonary hypertension was observed during the 3 last h of the study and was attributable to an increased pulmonary vascular resistance. Severe neutropenia was observed at 3 h p.i. and post-mortem histological findings were consistent with an acute fibrinohemorragic bronchopneumonia. In conclusion, P. haemolytica airway challenge unequiovocally resulted in acute pneumonia, providing a reproducible pathophysiological model for investigations regarding new therapeutic strategies.
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