Reference : Arguments en faveur de l'existence d'un inhibiteur endogène de la Na-K ATPase rénale,...
Scientific journals : Article
Human health sciences : Urology & nephrology
Arguments en faveur de l'existence d'un inhibiteur endogène de la Na-K ATPase rénale, de nature stéroïdienne et a vertu natriuretique
[en] Arguments for the Existence of an Endogenous Inhibitor of Renal Na-K Atpase with Steroid Structure and Natriuretic Action
Krzesinski, Jean-Marie mailto [Université de Liège - ULiège > > Néphrologie >]
Christiaens, L. [ > > ]
Palem-Vliers, M. [> > > >]
Fenghe, D. [> > > >]
Pequeux-Bar, M. L. [> > > >]
Lomba-Pignon, M. R. [> > > >]
Genard, P. [> > > >]
Rorive, Georges mailto [Université de Liège - ULiège > Département des sciences cliniques > Département des sciences cliniques >]
Archives des Maladies du Coeur et des Vaisseaux
J. B. Bailliere et Fils
Yes (verified by ORBi)
[fr] natriurèse ; NA-K ATPase rénale ; dérivés (" 7 dihydroxy-6, 7-dihydro-canrénone
[en] In order to explain the opposite effect of 6,7-dihydroxylated isomers of 6, 7 - dihydrocanrenone on the urinary sodium and potassium excretion, we have tested the effect of these substances isolated from human urine on the Na(+)-K+ pump from different tissue preparation: rabbit kidney slices as well as NA-K ATPase purified from the kidney. Our results show an inhibition of pump as well as enzyme activity by the 6 beta 7 alpha isomer while the 2 other isomers are either uneffective or slightly stimulating. The 6 beta 7 alpha dihydroxy-6, 7-dihydrocanrenone could be one of the plasma ouabain-like substance incriminated in the pathogenesis of volume-expanded hypertension.
Researchers ; Professionals

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1990 Arch Mal Coeur 83 1229-1231001.pdfPublisher postprint2.77 MBRequest copy

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