Four years of induction/synchronization of estrus in dairy goats: effect on the evolution of eCG binding rate in relation with the parameters of reproduction
Drion, Pierre; Furtoss, V.; Baril, G.et al.
2001 • In Reproduction Nutrition Development, 41 (5), p. 401-412
[en] Ninety-eight Alpine goats of two herds were followed over 4 years in a program of annual artificial insemination after estrus induction/synchronization, including progestagen administration (vaginal sponge) followed by prostaglandin analog and equine chorionic gonadotrophin (eCG) 48 h before sponge removal. Goats were sampled every 4 hours from the 16th to the 56th following sponge removal, for determination of LH surge and tested for estrus by the presence of a buck. Seven days after AI, endoscopic examination of the ovaries was performed to determine the number of corpus lutea. Pregnancy diagnosis was performed at day 21-22 post AI by determination of plasma progesterone and at day 40-45 by ultrasonography. Parturition, number and sex of kids were recorded. All the goats were sampled before and after each treatment, for anti-eCG antibodies screening. Statistical analysis of the results clearly established a significant effect of the treatments on anti-eCG antibodies. Time of estrus and LH surge were significantly different between herd. The antibodies significantly delayed the time of coming out of estrus as well as the time of LH surge. Two antagonistic effects were evidenced: first, the delayed of time of estrus and time of LH surge in relation with the immune reaction to eCG; secondly, the ahead of time of estrus and time of LH surge during the years of treatment, identical to both herd. The antibodies negatively influenced the percentage of ovulating females as well as kidding rate. Finally, no effect of antibodies on prolificacy was found.
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Drion, Pierre ; Université de Liège - ULiège > Services généraux de l'Université
Furtoss, V.
Baril, G.
Manfredi, E.
Bouvier, F.
Pougnard, J. L.
Bernelas, D.
Caugnon, P.
McNamara, E. M.
Remy, Benoit
Sulon, Joseph ; Université de Liège - ULiège > Département de sciences fonctionnelles > Physiologie de la reproduction
Beckers, Jean-François ; Université de Liège - ULiège > Département de sciences fonctionnelles > Physiologie de la reproduction
Four years of induction/synchronization of estrus in dairy goats: effect on the evolution of eCG binding rate in relation with the parameters of reproduction
Baril G., Saumande J. (2000) Hormonal treatments to control time of ovulation and fertility of goats. VIIth International Conference on Goats , Gruner L., Chabert Y. (Eds), LIR Press, Ivrysur-Seine, France; 400-405.
Baril G., Leboeuf B., Saumande J. (1993) Synchronization of estrus in goats: The relationship between time of occurrence of estrus and fertility following artificial insemination. Theriogenology 40:612-628.
Baril G., Remy B., Leboeuf B., Beckers J.F., Saumande J. (1996) Synchronization of oestrus in goats: The relationship between eCG binding in plasma, time occurrence of oestrus and fertility following artificial insemination. Theriogenology 45:1553-1559.
Beckers J.F., Remy B., Baril G., Figueiredo J.R., Bureau F., Sulon J., Saumande J. (1995) Anti-eCG antibodies are transmitted via the colostrum in goats. Theriogenology 43:165.
Boime I., Ben-Menahem D. (1999) Glycoprotein hormone structure-function and analog design. Recent Prog. Horm. Res 54:271-289.
Christakos C., Bahl O.P. (1979) Pregnant Mare Serum Gonadotrophin. Purification and physiochemical, biological and immunological characterization. J. Biol. Chem 254:4253-4261.
Clarke I.J. (1973) Repeated gonadotrophic stimulation of ewes. New Zeal. Soc. Anim. Prod 33:204.
Corteel J.M., Leboeuf B., Baril G. (1988) Artificial breeding of goats and kids induced to ovulate with hormones outside the breeding season. Small Rum. Res 1:19-35.
Drion P.V., Remy B., Houtain J.Y., McNamara M., Baril G., Cognie Y., Heyman Y., Leboeuf B., Theau-Clément M., Desbuleux H., Ectors F.J., Ectors F., Beckers J.F. (1998) Utilisation répétée des gonadotropines exogènes dans le contrôle de la reproduction: Justifications, relations structure-activité biologique, effets secondaires potentiels, Une synthèse. Ann. Med. Vet 142:373-396.
Evans G. (1988) Current topics in artificial insemination of sheep. Aust. J. Biol. Sci 41:103-116.
Freitas V.J.F., Baril G., Bosc M., Saumande J. (1996) The influence of ovarian status on response to estrus synchronization treatment in dairy goats during the breeding season. Theriogenology 45:1561-1567.
Freitas V.J.F., Baril G., Saumande J. (1996) Induction and synchronization of estrus in goats: The relative efficiency of one versus two fluorogestone acetate-impregnated vaginal sponges. Theriogenology 46:1251-1256.
Freitas V.J., Baril G., Martin G.B., Saumande J. (1997) Physiological limits to further improvement in the efficiency of oestrous synchronization in goats. Reprod. Fertil. Dev 9:551-556.
Joshi L., Murata Y., Wondisford F.E., Szkudlinski M.W., Desai R., Weintraub B.D. (1995) Recombinant thyrotropin containing a beta-subunit chimera with the human chorionic gonadotropin-beta carboxy-terminus is biologically active, with a prolonged plasma half-life: Role of carbohydrate in bioactivity and clearance. Endocrinology 136:3839-3848.
Leboeuf B., Bernelas D., Pougnard J.L., Baril G., Maurel M.C., Boue P., Terqui M. (1993) Time of ovulation after LH peak in dairy goats induced to ovulate with hormonal treatment, European embryo transfer association meeting. Lyon 226.
Littell R.C., Henry P.R., Ammerman C.B. (1998) Statistical analysis of repeated measures data using SAS procedures. J. Anim. Sci 76:1216-1231.
Maurer R.R., Hunt W.L., Foote R.H. (1968) Repeated superovulation following administration of exogenous gonadotropins in Dutch-belted rabbits. J. Reprod. Fertil 15:93-102.
Moore N.W., Eppleston J. (1979) The control of oestrus, ovulation and fertility in relation to artificial insemination in the angora goat. Aust. J. Agric. Res 30:965-972.
Remy B., Baril G., Vallet J.C., Dufour R., Chouvet C., Saumande J., Chupin D., Beckers J.F. (1991) Are antibodies responsible for a decrease superovulatory response in goats which have been treated repeatedly with porcine follicle-stimulating hormone?. Theriogenology 36:389-399.
Roser J.F., Kiefer B.L., Evans J.W., Neelly D.P., Pacheco C.A. (1979) The development of antibodies to human chorionic gonadotropin following its repeated injections in the cyclic mare. J. Reprod. Fertil 27:173-179.
Roulston J.E. (1979) Validation of the self-displacement technique for estimation of specific radioactivity of radioimmunoassay tracers. Ann. Clin. Biochem 16:26-29.
Rowe J.D., East N.E. (1996) Comparison of two sources of gonadotropin for estrus synchronization in does. Theriogenology 45:1569-1575.
Roy F., Maurel M.C., Combes B., Vaiman D., Cribiu E.P., Lantier I., Pobel T., Deletang F., Combarnous Y., Guillou F. (1999) The negative effect of repeated equine chorionic gonadotropin treatment on subsequent fertility in Alpine goats is due to a humoral immune response involving the major histocompatibility complex. Biol. Reprod 60:805-813.
1988.
Steelman S.L., Pohley F.M. (1953) Assay of the follicle stimulating hormone based on the augmentation with human chorionic gonadotropin. Assay on FSH 53:604-616.
Thorell J.I., Johansson B.G. (1971) Enzymatic iodination of polypeptides with 125I to high specific activity. Biochim. Biophys. Acta 251:363-369.
