[en] The pregnancy-associated glycoprotein (PAG) concentration profiles of goats that had been experimentally inoculated with either Toxoplasma gondii or Listeria monocytogenes are described. All goats were examined regularly by ultrasonography. In T. gondii-infected females (n = 5), a slow decrease of PAG was observed throughout a period of 55 to 74 d after inoculation. Afterwards, the goats either aborted (n = 4) or kidded 1 dead and 1 weak fetus (n = 1). In L. monocytogenes-infected females (n = 8), a marked decrease of PAG was observed from the day of inoculation. Abortion occurred within 9 to 11 d post inoculation (n = 7). Only 1 goat kidded a healthy fetus.
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Zarrouk, A.
Engeland, I. V.
Sulon, Joseph ; Université de Liège - ULiège > Département de sciences fonctionnelles > Physiologie de la reproduction
Beckers, Jean-François ; Université de Liège - ULiège > Département de sciences fonctionnelles > Physiologie de la reproduction
Language :
English
Title :
Pregnancy-associated glycoprotein levels in pregnant goats inoculated with Toxoplasma gondii or Listeria monocytogenes: a retrospective study
Anderson ML, Barr BC, Conrad PA. Protozoal causes of reproductive failure in domestic ruminants. Veterinary Clinics of North America: Food Anim Prac 1994; 10:439-461.
Blundell TL, Guruprasad K, Albert Awilliams M, Sibanda BL, Dhanaraj V. The aspartic proteinases: An historical overview. In: James (ed), Aspartic Proteinases. NY: Plenium Press, 1998 436:1-13.
Carter JL, Chen CL, Dennis SM. Serum levels of progesterone, estradiol, and hydrocortisone in ewes after abortion due to Listeria monocytogenes type 5. Am J Vet Res 1976; 37:1071-1073.
Clemens LE, Siiteri PK, Stites DP. Mechanism of immunosuppression of progesterone on maternal lymphocyte activation during pregnancy. J Immunol 1979; 122:1978-1985.
Cooper J, Walker RD. Listeriosis. Veterinary Clinics of North America: Food Anim Prac 1998; 14:113-125.
Dubey JP. Toxoplasma-induced abortion in dairy goats. JAVMA 1981; 178:671-674.
Ectors FJ, Schmidt M, Sulon J, Delval A, Remy B, Avery B, Beckers JF. BPAG profiles in recipient heifers after transfer of IVF and nuclear transfer embryos. Theriogenology 1996; 45:283 abstr.
Engeland IV, Waldeland H, Kindahl H, Ropstad E, Andresen O. Effect of toxoplasma gondii infection on the development of pregnancy and on endocrine fœtal-placental function in the goat. Vet Parasitol 1996; 67:61-74.
Engeland IV, Waldeland H, Ropstad E, Kindahl H, Andresen O. Effect of experimental infection with Listeria monocytogenes on the development of pregnancy and on concentrations of progesterone, oestrone sulphate and 15 ketodihydro-PGF2a in the goat. Anim Reprod Sci 1997; 45:311-327.
Garbayo JM, Remy B, Alabart JL, Folch J, Wattiez R, Falmagne P, Beckers JF. Isolation and partial characterization of a pregnancy-associated glycoprotein family from the goat placenta. Biol Reprod 1998; 58:109-115.
Gray ML, Chintamani S, Thorp F Jr. Abortion and pre- Or postnatal death of young due to Listeria monocytogenes. III. Studies in ruminants. Am J Vet Res 1956; 17:510-516.
Humblot P, Courtin H, Jeanguyot N, Thibier M, Sasser RG. Pregnancy-specific protein B and oestrone sulfate concentrations during pregnancy and embryonic mortality in dairy goats. 12th Int Congr Anim Reprod 1992: 2 abstr.
Low JC, Donarchie W. A review of Listeria monocytogenes and listeriosis. The Veterinary Journal 1997; 153:9-29.
Pavia C, Siiteri PK, Perlman JD, Stites DP. Suppression of murine allogenic cell interactions by sex hormones. J Reprod Immunol 1979; 1:33-38.
Ranilla MJ, Gebbie FE, King ME, Carolan C, Sinclair KD, McEvoy TG, Beckers JF, Broadbent PJ, Robinson JJ. The incidence of embryo and fetal loss following the transfer of in vitro cultured sheep embryos. Theriogenology 1998; 49:248 abstr.
Roussev RG, Higgins NG, McIntyre JA. Phenotypic characterization of normal human placental mononuclear cells. J Reprod Immunol 1993; 25:15-29.
Siiteri PK, Stites DP. Immunologic and endocrine interrelationships in pregnancy. Biol Reprod 1982; 26:1-14.
Siiteri PK, Febres F, Clemens LE, Chang RJ, Gondos B, StitesD. Progesterone and the maintenance of pregnancy: Is progesterone nature's immunosuppresant? Ann NY Acad Sci 1977; 286: 384-397.
Smith RE, Reynolds IM, Clark GW, Milbury JA. Experimental ovine listeriosis. IV. Pathogenesis of fetal infection. Cornell Vet 1970; 60:450-62.
Szenci O, Taverne MAM, Beckers JF, Sulon J, Varga J, Börzsönyi L, Hanzen Ch, Schekk Gy. Evaluation of false ultrasonographic diagnoses in cows by measuring plasma levels of bovine pregnancy-associated glycoprotein 1. Vet Rec 1998; 142:304-306.
Sousa NM, Garbayo JM, Figueiredo JR, Sulon J, Gonçcalves PBD, Beckers JF. Pregnancy-associated glycoprotein and progesterone profiles during pregnancy and postpartum in native goats from the north-east of Brazil. Small Rumin Res 1998; 1739: 1-11.
Waldeland H. Toxoplasmosis in sheep. The relative importance of the infection as a cause of reproductive loss in sheep in Norway. Acta Vet Scand 1976; 17: 412-425.
Waldeland H, Loken T. Reproductive failure in goats in Norway: An investigation in 24 herds. Acta Vet Scand 1991; 32: 535-541.
Wallace JM, Aitken RP, Cheyne MA, Humblot P. Pregnancy-specific protein B and progesterone concentrations in relation to nutritional regimen, placental mass and pregnancy outcome in growing adolescent ewes carrying singleton fetuses. J Reprod Fertil 1997; 109:53-58.
Wooding FBP. Current topic: The synepitheliochorial placenta of ruminants: Binucleate cell fusion and hormone production. Placenta 1992; 13:101-113.
Zarrouk A, Engeland I, Sulon J, Beckers JF. Determination of pregnancy-associated glycoprotein concentrations in goats (capra hircus) with unsuccessful pregnancies: A retrospective study. Theriogenology 1999; 51: 1221-1231.