horse; synoviocytes; joint; osteoarthritis; free oxygen radicals; equine; articulation; osteoarthrite; formes activées de l’oxygène
Abstract :
[fr] L’ostéo-arthropathie dégénérative est une cause importante de morbidité chez le cheval. Elle provoque de la douleur et mène à la destruction du cartilage des articulations diarthrodiales. Dans cette pathologie, la membrane synoviale est un élément articulaire constitutif dont il n’est pas toujours tenu compte parce que ses modifications sont peu visibles ; pourtant son rôle dans l’articulation est crucial. Cette synthèse de la littérature reprend l’embryogenèse et l’aspect histologique des synoviocytes in vivo et in vitro, les données existantes sur leur production de médiateurs inflammatoires, d’enzymes protéolytiques, et de formes activées de l’oxygène, sur les composants du liquide synovial et sur leurs interactions avec les chondrocytes. Le nombre des études ne traitant que de l’espèce équine et de l’ostéo-arthropathie étant très limité, nous avons tenu compte des travaux faits sur d’autres espèces et d’autres formes d’atteinte articulaire pour donner une vue aussi complète que possible des mécanismes complexes, interdépendants et réciproques. [en] The degenerative osteoarthritis is a common source of disease in the horse, causing pain and leading finally to the destruction of the cartilage in the diarthrodial joints. The synovial membrane is a constitutive element of the joint, but often neglected due to its less obvious alterations, despite its crucial role. This review of literature considers the embryology, the histology of synoviocytes in vivo and in vitro, gives information about the production of inflammatory mediators, degrading enzymes, free oxygen radicals, about the composition of the synovial fluid and the interaction with chondrocytes. The number of studies on equine synoviocytes in osteoarthritis is very restricted, therefore we included studies in other species and other types of joint diseases to achieve a more complete image of the complex, interdependent and mutual acting mechanisms.
Research Center/Unit :
CORD - Centre de l'Oxygène, Recherche et Développement - ULiège Centre européen du Cheval de Mont-le-Soie
Disciplines :
Veterinary medicine & animal health Human health sciences: Multidisciplinary, general & others
Author, co-author :
Schneider, Nicole ; Université de Liège - ULiège > CARE "Le Réseau des bibliothèques" > Bibliothèque des Sciences de la vie
Lejeune, Jean-Philippe ; Université de Liège - ULiège > Département clinique des animaux de compagnie et des équidés > Anesthésiologie gén. et pathologie chirurg. des grds animaux
Deby-Dupont, Ginette
Serteyn, Didier ; Université de Liège - ULiège > Département clinique des animaux de compagnie et des équidés > Anesthésiologie gén. et pathologie chirurg. des grds animaux
Language :
French
Title :
Le rôle des synoviocytes dans l’articulation diarthrodiale enflammée
Alternative titles :
[en] The role of synoviocytes in the inflamed diarthrodial joint.
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