Article (Scientific journals)
P65 Homodimer Activity in Distal Airway Cells Determines Lung Dysfunction in Equine Heaves
Sandersen, Charlotte; Bureau, Fabrice; Turlej, R. et al.
2001In Veterinary Immunology and Immunopathology, 80 (3-4), p. 315-26
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Keywords :
Nuclear factor-κB; Lung resistance; Inflammation; Neutrophils
Abstract :
[en] Nuclear factor-kappaB (NF-kappaB) activity, which is a key regulator of inflammatory gene expression, is increased in bronchial epithelial cells from horses suffering from heaves (a hypersensitivity-associated inflammatory condition of the lung). To determine whether this increased activity extends to distal airways and to other pulmonary cells, cells recovered by broncho-alveolar lavage (BAL) in healthy and heaves-affected horses were assessed for NF-kappaB activity. NF-kappaB activity was much higher in BAL cells from heaves-affected horses, especially during crisis (disease exacerbation), than in cells from healthy horses. Moreover, the level of NF-kappaB activity found in BAL cells was positively correlated to total lung resistance and to the proportion of neutrophils present in BAL fluid. Finally, prototypical p65-p50 NF-kappaB heterodimers were absent from BAL cells, which mostly contained p65 homodimers. These results (1) show that increased NF-kappaB activity is a general feature of heaves lung; (2) demonstrate the importance of p65 homodimers in neutrophilic inflammation; and (3) suggest that the use of specific NF-kappaB inhibitors could improve lung function in heaves-affected horses.
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Sandersen, Charlotte  ;  Université de Liège - ULiège > Département clinique des animaux de compagnie et des équidés > Département clinique des animaux de compagnie et des équidés
Bureau, Fabrice ;  Université de Liège - ULiège > Département de sciences fonctionnelles > Biochimie et biologie moléculaire
Turlej, R.
Fievez, Laurence ;  Université de Liège - ULiège > Département de sciences fonctionnelles > Biochimie et biologie moléculaire
Dogne, S.
Kirschvink, N.
Lekeux, Pierre ;  Université de Liège - ULiège > Département de sciences fonctionnelles > Physiologie
Language :
English
Title :
P65 Homodimer Activity in Distal Airway Cells Determines Lung Dysfunction in Equine Heaves
Publication date :
10 August 2001
Journal title :
Veterinary Immunology and Immunopathology
ISSN :
0165-2427
eISSN :
1873-2534
Publisher :
Elsevier Science, Amsterdam, Netherlands
Volume :
80
Issue :
3-4
Pages :
315-26
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 20 February 2009

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