[en] Seven sport horses were investigated to compare physiological and pharmacological stresses on the plasma glucocorticosteroid levels.
Venous blond was sampled and analysed for cortisol concentrations before and after each type of stress. The physiological stress was induced by the completion of a cross-country and the phar¬macological one, by an intravenous ACTH administration (200 µg) in the came horses, one week after the course.
Both exercise and ACTH injection induced a highly significant cortisol increase of 79 ± 0.10 %, and 160 ± 0.18 %, respectively. The relative plasma cortisol increases due to exercise on the nue hand, and due to ACTH administration on the other hand, were correlated with a coefficient of 0.82. It was concluded that the plasma cortisol increase induced by a standardised pharmacological stress could be used in order to predict the exercise-induced stress response.
Disciplines :
Anatomy (cytology, histology, embryology...) & physiology Veterinary medicine & animal health
Author, co-author :
Linden, Annick ; Université de Liège - ULiège > Faculty of Veterinary Medicine > Laboratory of Functional Investigation
Art, Tatiana ; Université de Liège - ULiège > Faculty of Veterinary Medicine > Laboratory of Functional Investigation
Amory, Hélène ; Université de Liège - ULiège > Faculty of Veterinary Medicine > Laboratory of Functional Investigation
Desmecht, Daniel ; Université de Liège - ULiège > Faculty of Veterinary Medicine > Laboratory of Functional Investigation
Lekeux, Pierre ; Université de Liège - ULiège > Faculty of Veterinary Medicine > Laboratory of Functional Investigation
Language :
English
Title :
Comparison of the adrenocortical response to both pharmacological and physiological stresses in sport horses
Publication date :
1990
Journal title :
Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine
Bottoms G.D., Roesel O.F., Rausch F.D., Akins E.L. (1972) Circadian variation inplasma Cortisol and corticosterone in pigs and mares. Am. J. Vet. Res. 33:785-790.
Church D.B., Evans D.L., Lewis D.R., Rose R.J. (1987) The effect of exercise on plasmaadrenocorticotrophin, Cortisol and insulin in the horse and adaptations with training. EquineExercise Physiology 2 , ICEEP Publications, Davis, California, pp.; 506-515.
Dybdal N.O., Gribble D., Madigan J.E., Stabenfeldt G.H. (1980) Alterations in plasmacorticosteroids, insulin and selected metabolites in horses used in endurance rides. Eq. Vet. J. 12:137-140.
Edqvist L.E., Johansson E.D.B. (1972) Radioimmunoassay of oestrone and oestradiol inhuman and bovine peripheral plasma. Acta Endocr. (Khb.) 71:716-730.
Eiler H., Oliver J., Goble D. (1980) Combined dexamethasone‐suppression cosyntropin‐(synthetic ACTH‐) stimulation test in the horse: a new approach to testing of adrenal glandfunction. Am. J. Vet. Res. 41:430-434.
Fogarty U., Leadon D. (1987) “Poor performance” syndrome: a review of the literature andsome data on the haematological and blood biochemical changes in two groups of thoroughbredracehorses performing below expectation. Irish Vet. Journal 41:203-209.
Hoffsis G.F., Murdick P.W., Tharp V.L., Ault K. (1970) Plasma concentrations of Cortisol and corticosterone in the normal horse. Am. J. Vet. Res. 31:1379-1387.
James V.H.T., Horner M.W., Moss M.S., Rippon A.E. (1970) Adrenocortical function in the horse. J. Endocr. 48:319-335.
Larsson M., Edqvist L.‐E., Ekman L., Persson S. (1979) Plasma Cortisol in the horse, diurnal rhythm and effects of exogenous ACTH. Acta Vet. Scand. 20:16-24.
Linden A., Art T., Amory H., Desmecht D., Rollin F., Leroy P., Massart A.‐M., Bur‐venich C., Lekeux P. Changes in plasma Cortisol and lactate concentrations associated with 5 competitive sports in horses1990.
McHarg M.A., Bottoms G.D., Carter G.K., Johnson M.A. (1985) Effects of multiple intramuscular injections and doses of dexamethasone on plasma Cortisol concentrations and adrenal responses to ACTH in horses. Am. J. Vet. Res. 46:2285-2287.
Palmer J.E., Whitlock R.H., Deem D.A. (1982) The adrenal gland: ACTH stimulation test. Equine Medicine and Surgery , Mansmann, R. A., E. S. McAllister, P. W. Pratt, Santa Barbara, California, American Veterinary Publication Inc.; 902.
Persson S.G.B., Larsson M., Lindholm A. (1980) Effects of training on adreno‐cortical function and red‐cell volume in trotters. Zbl. Vet. Med. A 27:261-268.
Ralston J.M., Stenhouse A.M., Stenhouse N.S., Buck G.J., Lucks S.F., Reynoldson J.A., Bolton J.R. (1988) Cortisol concentrations in blood and urine of horses. Austr. Vet. J. 65:1-5.
Snow D.H., Rose R.J. (1981) Hormonal changes associated with long distance exercise. Eq. Vet. J. 13:195-197.
Toutain P.L., Oukessou M., Autefage A., Alvinerie M. (1988) Diurnal and episodic variations of plasma hydrocortisone concentrations in horses. Domestic Anim. Endocrinol. 5:55-59.
