Article (Scientific journals)
The Effect of Intravenous Administration of Web 2086 on Paf-Induced Platelet Aggregation in Healthy Friesian Calves
Bastos da Silva, Miriam; Gustin, Pascal; Herion, Francine et al.
1997In Veterinary Research Communications, 21 (7), p. 521-531
Peer Reviewed verified by ORBi
 

Files


Full Text
BastosDaSilvaM_VetResComm_1997.pdf
Publisher postprint (2.13 MB)
Request a copy

All documents in ORBi are protected by a user license.

Send to



Details



Keywords :
aggregation; cattle; chromatography; platelet; platelet-activating factor; platelet-rich plasma; thienotriazolodiazepine
Abstract :
[en] The in vivo ability of the specific PAF-antagonist WEB 2086, a thienotriazolodiazepine, to inhibit platelet-activating factor (PAF) in cattle was investigated by in vitro determination of platelet aggregation curves. WEB 2086 was infused intravenously into a group of 5 healthy male Friesian calves in a dose of 3 mg/kg over 1 min. The resultant inhibition peaked between 30 min and 1 h after administration of WEB 2086. The inhibition was significantly reduced after 3 h and became non-significant after 6 h, but maximal pre-treatment aggregation had not been restored by 24 h after the injection of WEB 2086. These results confirm previous results obtained in vitro and suggest that WEB 2086 is a potent antagonist of PAF activity in calves. They also suggest that further clinical studies with WEB 2086 in cattle are desirable.
Disciplines :
Veterinary medicine & animal health
Anatomy (cytology, histology, embryology...) & physiology
Author, co-author :
Bastos da Silva, Miriam;  Université de Liège - ULiège > Faculty of Veterinary Medicine > Laboratory of Functional Investigation
Gustin, Pascal ;  Université de Liège - ULiège > Faculty of Veterinary Medicine > Laboratory of Pharmacology and Toxicology
Herion, Francine ;  Centre Hospitalier Universitaire de Liège - CHU > Thrombosis Homestasis Unit
Raskinet, Renée ;  Centre Hospitalier Universitaire de Liège - CHU > Thrombosis Homestasis Unit
David, Jean-Louis ;  Centre Hospitalier Universitaire de Liège - CHU > Thrombosis Homestasis Unit
Gougnard, Thierry;  Centre Hospitalier Universitaire de Liège - CHU > Laboratory of Clinical Toxicology
Plomteux, Guy ;  Centre Hospitalier Universitaire de Liège - CHU > Laboratory of clinical toxicology
Desmecht, Daniel ;  Université de Liège - ULiège > Faculty of Veterinary Medicine > Laboratory of Functional Investigation
Lekeux, Pierre ;  Université de Liège - ULiège > Faculty of Veterinary Medicine > Laboratory of Functional Investigation
Language :
English
Title :
The Effect of Intravenous Administration of Web 2086 on Paf-Induced Platelet Aggregation in Healthy Friesian Calves
Publication date :
1997
Journal title :
Veterinary Research Communications
ISSN :
0165-7380
Publisher :
Kluwer Academic Publishers, Dordrecht, Netherlands
Volume :
21
Issue :
7
Pages :
521-531
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico [BR]
Funding text :
Bastos is a recipent of a grant from CNPq and FCAP Belém-Parà Brazil
Available on ORBi :
since 20 February 2009

Statistics


Number of views
110 (7 by ULiège)
Number of downloads
1 (1 by ULiège)

Scopus citations®
 
4
Scopus citations®
without self-citations
2
OpenCitations
 
2

Bibliography


Similar publications



Contact ORBi