[en] The use of lung scintigraphy in calves necessitates the validation of a ventilation (V) imaging agent compatible with clinical applications. This study aimed at defining the value of an inhaled radioactive aerosol (99mTc-DTPA) and a 'pseudogas' (Technegas) in the assessment of regional V in healthy conscious calves by comparing 99mTc-DTPA and Technegas deposition (D) images to V(V) images obtained from the steady-state inhalation of the short half-life krypton 81 (81mKr) gas. Images were compared by analysis of radioactivity distribution in computer-generated regions of interest within the right lung and D to V ratio images were generated in order to highlight areas of mismatching between 99mTc-DTPA or Technegas and 81mKr distributions. Results of this analysis showed that the 99mTc-DTPA aerosol droplets were unable to reach the lung parenchyma because of significant particle impaction in the major conducting airways. Better definition of the ventilated lung was obtained when using Technegas because of minimal deposition in conducting airways. Furthermore, the Technegas and 81mKr distribution patterns were highly equivalent.
Research Center/Unit :
Laboratoire d'Investigation fonctionnelle, service de Physiologie
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Coghe, Joost; Université de Liège - ULiège > Faculty of Veterinary Medicine > Laboratory for functional investigation
Votion, Dominique ; Université de Liège - ULiège > Faculty of Veterinary Medicine > Laboratory for Functional Investigation
Lekeux, Pierre ; Université de Liège - ULiège > Faculté de Médecine Vétérinaire > Laboratory for Functional Investigation
Language :
English
Title :
Comparison between Radioactive Aerosol, Technegas and Krypton for Ventilation Imaging in Healthy Calves
Publication date :
July 2000
Journal title :
Veterinary Journal
ISSN :
1090-0233
eISSN :
1532-2971
Publisher :
Elsevier
Volume :
160
Issue :
1
Pages :
25-32
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
Ministère de l'Agriculture et des Classes Moyennes FRIA - Fonds pour la Formation à la Recherche dans l'Industrie et dans l'Agriculture
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