Article (Scientific journals)
Equine pulmonary and systemic haemodynamic responses to endothelin-1 and a selective ETA receptor antagonist
Benamou, A. E.; Marlin, D. J.; Lekeux, Pierre
2001In Equine Veterinary Journal, 33 (4), p. 337-44
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Keywords :
horse; endothelin; in vivo; vasculature
Abstract :
[en] Based on previous in vitro studies, we hypothesised that endothelin (ET) would induce vasoconstriction in the pulmonary circululation of the horse and that this action would be mediated via ET(A) receptors. Pulmonary and systemic haemodynamic responses to endothelin-1 (ET-1), a potent vasoactive endogenous peptide, were investigated in 6 conscious, nonsedated horses at rest. Bolus i.v. injections of exogenous ET-1 (0.1, 0.2 and 0.4 microg/kg bwt) caused significant increases in pulmonary (PAP) and carotid (CAP) artery pressures, with peak increases of 79% and 51% for mean PAP and CAP, respectively. The effect of ET-1 on PAP and CAP was rapid and transient for PAP (-10 min) but prolonged for CAP (up to 60 min). ET-1 significantly decreased cardiac output by up to 35% and significantly increased systemic vascular resistance (SVR) by up to 104%. Pulmonary vascular resistance (PVR) showed a trend (P>0.05) to increase with 0.2 and 0.4 microg/kg bwt ET-1. Infusion of a selective ET(A) receptor antagonist (TBC11251) completely inhibited the responses to a subsequent bolus of 0.2 microg/kg bwt ET-1. We conclude that exogenous ET-1 exerts a potent vasoconstrictive action on the pulmonary and systemic circulations of the horse. These effects appear to be mediated largely through ET(A) receptors in both circulations. Endothelin may play a role in hypertensive conditions in the horse.
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Benamou, A. E.;  Université de Liège - ULiège > Faculty of Veterinary Medicine > Physiology
Marlin, D. J.;  Centre of Equine Studies, Anima health Trust, UK
Lekeux, Pierre ;  Université de Liège - ULiège > Faculty of Veterinary Medicine > Physiology
Language :
English
Title :
Equine pulmonary and systemic haemodynamic responses to endothelin-1 and a selective ETA receptor antagonist
Publication date :
2001
Journal title :
Equine Veterinary Journal
ISSN :
0425-1644
eISSN :
2042-3306
Publisher :
Equine Veterinary Journal Ltd, Newmarket Suffolk, United Kingdom
Volume :
33
Issue :
4
Pages :
337-44
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
Marjorie Coote Animal Charity Trust and the Animal Health Trust
Available on ORBi :
since 20 February 2009

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