Le cas clinique du mois. Kératoses et carcinomes arsenicaux.

Aged; Arsenic/adverse effects; Carcinoma, Basal Cell/chemically induced; Carcinoma, Squamous Cell/chemically induced; Humans; Keratosis/chemically induced; Male; Psoriasis/drug therapy; Skin Neoplasms/chemically induced

Abstract :

[en] We report the case of a 70-year old man who presented the classical cutaneous signs of chronic arsenicism : palmo-plantar keratoses and lesions of Bowen's disease. Within a few months, the patient developed multiple large superficial basal cell carcinomas on the trunk and several invasive squamous cell carcinomas. A pulmonary cancer with cerebral metastases was also identified. The complications of chronic arsenicism are nowadays rarely encountered. The cutaneous changes should be recongized because they allow to reveal the etiology of some internal lesions. Indeed, the notion of past arsenicism is often missing in the patient records. The recognition of the cutaneous warning signs allows to focus on the overall cancer risk of these patients.

Disciplines :

Dermatology

Author, co-author :

Fumal, I.; Centre Hospitalier Universitaire de Liège - CHU > Dermatopathologie

Pierard, Claudine ; Centre Hospitalier Universitaire de Liège - CHU > Dermatopathologie

Pierard, Gérald ; Centre Hospitalier Universitaire de Liège - CHU > Dermatopathologie

Language :

French

Title :

Le cas clinique du mois. Kératoses et carcinomes arsenicaux.

Alternative titles :

[fr] Arsenical keratoses and carcinomas.

Publication date :

2005

Journal title :

Revue Médicale de Liège

ISSN :

0370-629X

eISSN :

2566-1566

Publisher :

Université de Liège. Revue Médicale de Liège, Liège, Belgium

Volume :

Issue :

Pages :

217-21

Peer reviewed :

Peer reviewed

Available on ORBi :

since 19 February 2009

Statistics

Number of views

147 (0 by ULiège)

Number of downloads

393 (1 by ULiège)

More statistics

Scopus citations^®

Scopus citations^®
without self-citations

OpenAlex citations

Bibliography

Neubauer O.- Arsenical cancer: a review. Br J Cancer, 1947, 1, 192-251.
Robertson WO.- Arsenic and other heavy metals. In: Haddad LM, Winchester JF (eds). Clnical management of poisoning and drug overdose. W. Saunders, Philadelphia, PA, 1983, chap 59, p 656.
Schwartz RA.- Arsenicism and the skin. Int J Dermatol, 1997, 36, 241-250.
Nevens F, Fevery J, Van Steenbergen W.- Arsenic and non-cirrhotic portal hypertension. A report of eight cases. J. Hepatol, 1990, 11, 80-85.
Bettley FR, O'Shea JA.- The absorption of arsenic and its relation to carcinoma. Br J. Dermatol, 1975, 92, 563-568.
Centeno JA, Mullick FG, Martinez L et al.- Pathology related to chronic arsenic exposure. Environ Health Perspect, 2002, 110 Suppl, 5, 883-886.
Col M, Col C, Soran A et al.- Arsenic-related Bowen's disease, palmar keratosis and skin cancer. Environ Healt Perspect, 1999, 107, 687-689.
Bourgeois AM, Avenel Audran M, Le Bouil A, et al.- Arsėnicisme chronique. Ann Dermatol Venereol, 2001, 128, 527-530.
Lien HC, Tsai TF, Lee YY, et al.- Merckel cell carcinoma and chronic arsenicism. J Am Acad Dermatol, 1999, 41, 641-643.
Le Cam MT, Pairon JC.- L'arsénicisme chronique (éditorial). Ann Dermatol Venereal, 2001, 128, 493-495.
Das D, Chatterjee A, Mandal BIC et al.- Arsenic in ground water in six districts of west Bengal, India: the biggest arsenic calamity in the world. Part 2 - Arsenic concentration in drinking water, hair, nails, urine, skin-scale and liver tissue (biopsy) of the affected people. Analyst, 1995, 120, 917-924.
Wong SS, Tan KC, Goh CL.- Cutaneous manifestations of chronic arsenicism: review of seventeen cases. J Am Acad Dermatol, 1998, 38, 179-185.
Sass V, Grosshans E, Simonart JM.- Chronic arsenicism: criminal poisoning or drug-intoxication? Report of two cases. Dermatology, 1993, 186, 303-305.
Saha KC.- Diagnosis of arsenicosis. J. Environ Sci Health. Part a Tox Hazard Subst Environ Eng, 2003, 38, 255-272.
Yerebakan O, Ermis O, Yilmas E, et al.- Treatment of arsenical keratosis and Bowen's disease with acitretin. Int J Dermatol, 2002, 41, 84-87
Poljacki M, Stojanovic S, Svilar V- The importance of local administration of 5% 5-fluorouraril in the therapy of senile keratoses and basocellular carcinoma. Med Pregl, 1989, 42, 149-151.
Cowen E, Mercurio M, Gaspari A, et al.- An open cases series of patients with basal cell carcinoma treated with topical 5% imiquimod cream. J Am Acad Dermatol, 2002, 47, 5240-5248.
Hermanns-Lê J, Nikkels A, Uhoda I, et al.- L'imiquimod (Aldara°): un immunomodulateur pour la peau. Rev Med Liège, 2002, 57, 116-118.
Uhoda I, Quatresooz P, Piérard GE.- Nudging epidermal field cancerogenesis by imiquimod. Dermatology, 2003, 206, 357-360.
Hermanns-Lê T, Paquet P, Nikkels AJ, et al.- Prolonged imiquimod treatment and graft-versus-host reaction : histological mimicry in the pattern of monocyte-macrophage-dendrocyte lineage skin infiltration. Dermatology 2003, 206, 361-365.
Quatresooz P, Piérard GE.- Imiquimod-responsive basal cell carcinomas and factor XIIIa-enriched dendrocytes. Clin Exp Dermatol, 2003, 28, S27-S29.
Nikkels AF, Nikkels-Tassoudji N, Piérard GE.- Imiquimod-induced regression of superficial basal cell carcinoma: implication of factor XIIIa+ dermal dendrocytes. Clin Exp Dermatol, sous presse.