Measurement of respiratory function by impulse oscillometry in horses

[en] Reasons for performing study: Due to technical implementations and lack of sensitivity, pulmonary function tests are seldom used in clinical practice. Impulse oscillometry (IOS) could represent an alternative method. Objectives: To define feasibility, methodology and repeatability of IOS, a forced oscillation technique that measures respiratory resistance (R-rs) and reactance (X-rs) from 5 to 35 Hz during spontaneous breathing, in horses. Methods: Using 38 healthy horses, R-rs and X-rs reference values were defined and influence of individual biometrical parameters was investigated. In addition, IOS measurements of 6 horses showing clinical signs of heaves were compared to those of 6 healthy horses. Results: Airtightness and minimal dead space in the facemask were prerequisites to IOS testing and standardisation of head position was necessary to avoid variations in R-rs due to modified upper airway geometry. In both healthy and diseased animals, measurements were repeatable. In standard-type breeds, the influence of the horse's size on IOS parameters was negligible. An increase in R-5Hz greater than 0.10 kPa/l/sec and R-5Hz>R-10Hz, combined with negative values of X-rs between 5 and 20 Hz, was indicative of heaves crisis. Conclusions: IOS is a quick, minimally invasive and informative method for pulmonary function testing in healthy and diseased horses. Potential relevance: IOS is a promising method for routine and/or field respiratory clinical testing in the equine species.

Disciplines :

Veterinary medicine & animal health

Author, co-author :

Van Erck, Emmanuelle ; Université de Liège - ULiège > Faculté de Médecine Vétérinaire, Physiologie

Votion, Dominique ; Université de Liège - ULiège > Département clinique des animaux de compagnie et des équidés > Anesthésiologie gén. et pathologie chirurg. des grds animaux

Art, Tatiana ; Université de Liège - ULiège > Département de sciences fonctionnelles > Phys. neuro-muscul., de l'effort - Méd. sport. des animaux

Lekeux, Pierre ; Université de Liège - ULiège > Département de sciences fonctionnelles > Physiologie

Language :

English

Title :

Measurement of respiratory function by impulse oscillometry in horses

Publication date :

2004

Journal title :

Equine Veterinary Journal

ISSN :

0425-1644

eISSN :

2042-3306

Publisher :

Equine Veterinary Journal Ltd, Newmarket, United Kingdom

Volume :

Issue :

Pages :

21-28

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 29 June 2010

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Bibliography

Amis, T.C., Pascoe, J.R. and Hornof, W. (1984) Topographic distribution of pulmonary ventilation and perfusion in the horse. Am. J. vet. Res. 45, 1597-1601.
Art, T., Serteyn, D. and Lekeux, P. (1988) Effect of exercise on the partitioning of equine respiratory resistance. Equine vet. J. 20, 268-273.
Bisgaard, H. and Klug, B. (1995) Lung function measurement in awake young children. Eur. Respir. J. 8, 2067-2075.
Broadstone, R.V., Scott, J.S., Derksen, F.J. and Robinson, N.B. (1988) Effects of atropine in ponies with recurrent airway obstruction. J. appl. Physiol. 65, 2720-2725.
Cauberghs, M. and van de Woestijne, K.P. (1989) Effect of upper airway shunt and series properties on respiratory impedance measurements. J. appl. Physiol. 66, 2274-2279.
Cauberghs, M. and van de Woestijne, K.P. (1992) Changes of respiratory input impedance during breathing in humans. J. appl. Physiol. 73, 2355-2362.
Clement, J., Landser, F.J. and van de Woestijne, K.P. (1983) Total resistance and reactance in patients with respiratory complaints with and without airways obstruction. Chest 83, 215-220.
Clercx, C., Gustin, P., Landser, F.J. and van de Woestijne, K.P. (1993) Measurement of total respiratory impedance in dogs by the forced oscillation technique. Vet. res. Comm. 17, 227-239.
Couetil, L.L., Rosenthal, F.S., DeNicola, D.B. and Chilcoat, C.D. (2001) Clinical signs, evaluation of bronchoalveolar lavage fluid, and assessment of pulmonary function in horses with inflammatory respiratory disease. Am. J. vet. Res. 62, 538-546.
Cutillo, A.G. and Renzetti, A.D. Jr. (1993) Mechanical behavior of the respiratory system as a function of frequency in health and disease. Bull. Eur. Physiopathol. Respir. 19, 293-326.
Derksen, F.J. and Robinson, N.B. (1980) Esophageal and intrapleural pressures in the healthy conscious pony. Am. J. vet. Res. 41, 1756-1761.
Derksen, F.J., Stick, J.A., Scott, E.A., Robinson, N.E. and Slocombe, R.F. (1986) Effect of laryngeal hemiplegia and laryngoplasty on airway flow mechanics in exercising horses. Am. J. vet. Res. 47, 16-20.
Desager, K.N., Buhr, W., Willemen, M., van Bever, H.P., de Backer, W., Vermeire, P.A. and Landser, F.J. (1991) Measurement of total respiratory impedance in infants by the forced oscillation technique. J. appl. Physiol. 71, 770-776.
Duvivier, D.H., Votion, D., Vandenput, S., Art, T. and Lekeux, P. (1997) Airway response of horses with COPD to dry powder inhalation of ipratropium bromide. Vet. J. 154, 149-153.
Finucane, K.E., Dawson, S.V., Phelan, P.D. and Mead, J. (1975) Resistance of intrathoracic airways of healthy subjects during periodic flow. J. appl. Physiol. 38, 517-530.
Fredberg, J.J. and Mead, J. (1979) Impedance of intrathoracic airway models during low frequency periodic flow. J. appl. Physiol.: Respir. Environ. Exerc. Physiol. 47, 347-351.
Gustin, P., Dhem, A.R., Lomba, F., Lekeux, P., van de Woestijne, K.P. and Landser, F.J. (1988) Measurement of total respiratory impedance in calves by the forced oscillation technique. J. appl. Physiol. 64, 1786-1791.
Gustin, P., Dhem, A.R., Lekeux, P., Lomba, F., Landser, F.J. and van de Woestijne, K.P. (1989) Regulation of bronchomotor tone in conscious calves. J. vet. Pharmacol. Ther. 12, 58-64.
Hoffman, A.M., Mazan, M.R. and Ellenberg, S. (1998) Association between bronchoalveolar lavage cytologic features and airway reactivity in horses with a history of exercise intolerance. Am. J. vet. Res. 59, 176-181.
Holcombe, S.J., Beard, W.L. and Hinchcliff, K.W. (1996) Effect of a mask and pneumotachograph on tracheal and nasopharyngeal pressures, respiratory frequency, and ventilation in horses. Am. J. vet. Res. 57, 250-253.
Klug, B. (1997) The impulse oscillation technique applied for measurements of respiratory function in young children. Pediatr. Pulmonol., Suppl. 16, 240-241.
Lavoie, J.P., Pascoe, J.R. and Kurpershoek, C.J. (1992) Effects of xylazine on ventilation in horses. Am. J. vet. Res. 53, 916-920.
Liistro, G., Stanescu, D., Dooms, G., Rodenstein, D. and Veriter, C. (1988) Head position modifies upper airway resistance in men. J. appl. Physiol. 64, 1285-1288.
Michaelson, E.D., Grassman, E.D. and Peters, W.R. (1975) Pulmonary mechanics by spectral analysis of forced random noise. J. clin. Invest. 56, 1210-1230.
Nyman, G., Lindberg, R., Weckner, D., Bjork, M., Kvart, C., Persson, S.G., Gustafsson, H. and Hedenstierna, G. (1991) Pulmonary gas exchange correlated to clinical signs and lung pathology in horses with chronic bronchiolitis. Equine vet. J. 23, 253-260.
Peslin, R. and Fredberg, J.J. (1986) Oscillation mechanics of the respiratory system. In: Handbook of Physiology, Vol. III, Mechanics of Breathing, Ed: A.P. Fischman, Williams & Wilkins Co., Baltimore, Maryland. pp 145-177.
Peslin, R., Duvivier, C. and Gallina, C. (1985) Total respiratory input and transfer impedances in humans. J. appl. Physiol. 59, 492-501.
Petsche, V.M., Derksen, F.J., Berney, C.E. and Robinson, N.B. (1995) Effect of head position on upper airway function in exercising horses. Equine vet. J. 18, 18-22.
Reinhold, P., MacLeod, D. and Lekeux, P. (1996) Comparative evaluation of impulse oscillometry and a monofrequency forced oscillation technique in clinically healthy calves undergoing bronchochallenges. Res. vet. Sci. 61, 206-213.
Reinhold, P., Smith, H.-J., Langenberg, A. and Lekeux, P. (1998a) Measurement of respiratory impedance in healthy calves using the impulse oscillation technique - physiological and methodological aspects. Vet. J. 155, 27-38.
Reinhold, P., Smith, H.-J., Close, R., Genicot, B. and Lekeux, P. (1998b) Validation of impulse oscillometry in Friesian and Blue Belgian calves with respect to changes in extrathoracic upper airway resistance. Res. vet. Sci. 65, 93-102.
Robinson, N.E. (1982) Some functional consequences of species differences in lung anatomy. Adv. vet. Sci. Comp. Med. 26, 1-33.
Robinson, N.E. and Sorenson, P.R. (1978) Collateral flow resistance and time constants in dog and horse lungs. J. appl. Physiol. 44, 63-68.
Robinson, N.E., Olszewski, M.A., Boehler, D., Berney, C., Hakala, J., Matson, C. and Derksen, F.J. (2000) Relationship between clinical signs and lung function in horses with recurrent airway obstruction (heaves) during a bronchodilator trial. Equine vet. J. 32, 393-400.
Uystepruyst, C., Reinhold, P., Coghe, J., Bureau, F. and Lekeux, P. (2000) Mechanics of the respiratory system in healthy newborn calves using impulse oscillometry. Res. vet. Sci. 68, 47-55.
Vandenput, S., Votion, D., Duvivier, D.H., van Erck, E., Anciaux, N., Art, T. and Lekeux, P. (1998) Effect of a set stabled environmental control on pulmonary function and airway reactivity of COPD affected horses. Vet. J. 155, 189-195.
van de Woestijne, K.P., Desager, K.N., Duiverman, E.J. and Marshal, F. (1994) Recommendations for the measurement of respiratory input impedance by means of the forced oscillation method. Eur. Respir. Rev. 4, 235-237.
van Erck, E., Votion, D., Kirschvink, N., Genicot, B., Lindsey, J., Art, T. and Lekeux, P. (2004) Influence of breathing pattern and lung inflation on impulse oscillometry measurments. Vet. J. In Press.
van Noord, J.A., Clement, J., van de Woestijne, K.P. and Demedts, M. (1989) Total respiratory resistance and reactance as a measurement of response to bronchial challenge with histamine. Am. Rev. Respir. Dis. 139, 921-926.
Vogel, J. and Smidt, U. (1994) Impulse Oscillometry: Analysis of Lung Mechanics in General Practice and the Clinic, Epidemiological and Experimental Research, PMI Verlag Gruppe, Frankfurt-am Main.
Young, S.S. and Hall, L.W. (1989) A rapid non-invasive method for measuring total respiratory impedance in the horse. Equine vet. J. 21, 99-105.
Young, S.S. and Tesarowski, D. (1994) Respiratory mechanics of horses measured by conventional and forced oscillation techniques. J. appl. Physiol. 76, 2467-2472.