Article (Scientific journals)
Are Amphipathic Asymmetric Peptides Ubiquitous Structures For Membrane Destabilisation?
Rahman, M.; Lins, Laurence; Thomas, Annick et al.
1997In Journal of Molecular Modeling, 3 (5), p. 203-215
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Abstract :
[en] The fusion of some viruses (SIV, BLV, etc) to host cells implicates short fragments of the fusion protein that are asymmetric amphipathic helices in molecular modelling. The tilted orientation of these fragments at a water/lipid interface is directly related to their fusogenic capacity. On this basis, we have searched for fragments of sequences corresponding to “viral fusion peptides” in other proteins. We have developed a strategy to detect them from primary sequences. Many candidates were detected, especially in transmembrane areas of membranous proteins, in signal sequences and in globular proteins. We suggest that they are involved in the dynamics of lipid-protein interactions.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Rahman, M.
Lins, Laurence  ;  Université de Liège - ULiège > Gembloux Agro-Bio Tech
Thomas, Annick ;  Université de Liège - ULiège > Chimie et bio-industries > Centre de Bio. Fond. - Section de Biologie moléc. et numér.
Brasseur, Robert ;  Université de Liège - ULiège > Gembloux Agro-Bio Tech
Language :
English
Title :
Are Amphipathic Asymmetric Peptides Ubiquitous Structures For Membrane Destabilisation?
Publication date :
1997
Journal title :
Journal of Molecular Modeling
ISSN :
1610-2940
eISSN :
0948-5023
Publisher :
Springer, Germany
Volume :
3
Issue :
5
Pages :
203-215
203-215
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 29 June 2010

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