[en] The fusion of some viruses (SIV, BLV, etc) to host cells implicates short fragments of the fusion protein that are asymmetric amphipathic helices in molecular modelling. The tilted orientation of these fragments at a water/lipid interface is directly related to their fusogenic capacity. On this basis, we have searched for fragments of sequences corresponding to “viral fusion peptides” in other proteins. We have developed a strategy to detect them from primary sequences. Many candidates were detected, especially in transmembrane areas of membranous proteins, in signal sequences and in globular proteins. We suggest that they are involved in the dynamics of lipid-protein interactions.
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Bibliography
Horth, M.; Lambrecht, B.; Chuah Lay Khim, M.; Bex, F.; Thiriart, C.; Ruysschaert, J.-M.; Burny, A.; Brasseur, R. The EMBO Journal 1991, 10, 2747-2755.
Vonèche, V.; Portetelle, D.; Kettmann, R.; Willems, L.; Limbach, K.; Paoletti, E.; Ruysschaert, J.-M.; Burny, A.; Brasseur, R. Proc. Natl. Acad. Sci. USA 1992, 89, 3810-3814.
White, J.M. Science 1992, 258, 917-924.
Wharton, S.A.; Martin, S.R.; Ruigrok, R.W.H.; Skehel, J.J.; Wiley, D.C J. Gen. Virol. 1988, 69, 1847-1857.
Burny, A.; Bex, F.; Brasseur, R.; Chuah Lay Khim, M.; Delchambre, M.; Horth, M.; Verdin, E. Journal of Acquired Immune Deficiency Syndromes 1988, 1, 579-282.
Martin, I.; Defrise-Quertain, F.; Mandieau, V.; Nielsen, N. M.; Saemark, T.; Burny, A.; Brasseur, R.; Ruysschaert, J.-M.; Vandenbranden, M. Biochem. Biophys. Res. Communications 1991, 175, 872-879.
Carr, C.M.; Kim, P.S. Cell 1993, 73, 823-832.
Desmet, J.; de Mayer, M. and Lasters, I. The "dead-end elimination" theorem: a new approach to the side-chain packing problem. In K. Merz, Jr. and S. Legrand (eds), The Protein Folding Problem and Tertiary Structure Prediction 1994.
Brasseur, R.; Ruysschaert, J.-M. Biochem. J. 1986, 239, 1-11.
Brasseur, R. J. Mol. Graphics 1995, 13, 312-322.
Rahman, M.; Brasseur, R. J. Mol. Graphics 1994, 12, 212-218.
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