Vasopressin-neurophysin and DST in major depression : Relationship with suicidal behavior.

[en] The purpose of the present study was to assess if AVP-neurophysin is associated with hypercortisolemia and suicidal behaviour in depressed patients. The study included 28 patients subgrouped into suicide attempters (n=13) and nonattempters (n=15). We assessed basal AVP-neurophysins concentrations and post-dexamethasone (DST) cortisol levels. Concentrations of AVP-neurophysins did not differ between DST suppressors and nonsuppressors: 0.29+/-0.13ng/ml vs 0.36+/-0.21ng/ml, (F=1.1, df=1, 27, p=0.30). Suicide attempters did not differ from nonattempters for AVP-neurophysins levels. Our results fail to support a role of AVP in the early cortisol escape.

Disciplines :

Psychiatry

Author, co-author :

Pitchot, William ; Centre Hospitalier Universitaire de Liège - CHU > Psychiatrie et psychologie médicale

Scantamburlo, Gabrielle ; Université de Liège - ULiège > Département des sciences cliniques > Département des sciences cliniques

Pinto, Emmanuel ; Centre Hospitalier Universitaire de Liège - CHU > Psychiatrie et psychologie médicale

Hansenne, Michel ; Université de Liège - ULiège > Département des sciences cognitives > Psycho. de la personnalité et des différences individuelles

Reggers, Jean ; Centre Hospitalier Universitaire de Liège - CHU > HOSPITALISATION - PSYCHO & PSYCHIATRIE T3 -3E - Psychiatrie et psychologie médicale

Ansseau, Marc ; Université de Liège - ULiège > Département des sciences cliniques > Psychiatrie et psychologie médicale

Legros, Jean-Jacques ; Université de Liège - ULiège > Département des sciences cliniques > Département des sciences cliniques

Language :

English

Title :

Vasopressin-neurophysin and DST in major depression : Relationship with suicidal behavior.

Publication date :

2008

Journal title :

Journal of Psychiatric Research

ISSN :

0022-3956

eISSN :

1879-1379

Publisher :

Elsevier, United Kingdom

Volume :

Pages :

684-688

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 17 February 2009

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