Insulinotropic action of (2S)-2-benzyl-3-(cis-hexahydro-2-isoindolinylcarbonyl) propionate. II. Ionophoretic and conformational aspects.

Malaisse, W. J.; Nadi, A. B.; Malaisse-Lagae, F.; Sato, F.; Lins, Laurence; Brasseur, Robert

doi:10.1016/0306-3623(94)00316-F

Article (Scientific journals)

Insulinotropic action of (2S)-2-benzyl-3-(cis-hexahydro-2-isoindolinylcarbonyl) propionate. II. Ionophoretic and conformational aspects.

Malaisse, W. J.; Nadi, A. B.; Malaisse-Lagae, F. et al.

1995 • In General Pharmacology, 26 (6), p. 1319-25

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/63800

DOI
10.1016/0306-3623(94)00316-F

PubMed
7590126

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Keywords :

Animals; Calcium/metabolism/pharmacology; Cations/metabolism; Hypoglycemic Agents/chemistry/pharmacology; Indoles/chemistry/pharmacology; Ionophores; Isoindoles; Models, Molecular; Molecular Structure; Rats

Abstract :

[en] 1. The non-sulphonylurea insulinotropic agent sodium (2S)-2-benzyl-3-(cis-hexahydro-2-isoindolinylcarbonyl) propionate (KAD-1229) was found to display calcium ionophoretic activity in an artificial membrane model. 2. Conformation analysis indicated that a complex between calcium and KAD-1229, with a 1:2 stoichiometry, indeed displays favourable attributes for ionophoretic activity across a hydrophobic environment. 3. It is speculated that the ionophoretic property of KAD-1229 might participate to the remodelling of cationic fluxes evoked by this insulinotropic agent in pancreatic islet cells.

Disciplines :

Biochemistry, biophysics & molecular biology

Author, co-author :

Malaisse, W. J.

Nadi, A. B.

Malaisse-Lagae, F.

Sato, F.

Lins, Laurence ; Université de Liège - ULiège > Gembloux Agro-Bio Tech

Brasseur, Robert ; Université de Liège - ULiège > Gembloux Agro-Bio Tech

Language :

English

Title :

Insulinotropic action of (2S)-2-benzyl-3-(cis-hexahydro-2-isoindolinylcarbonyl) propionate. II. Ionophoretic and conformational aspects.

Publication date :

1995

Journal title :

General Pharmacology

ISSN :

0306-3623

Publisher :

Elsevier Science, Exeter, United Kingdom

Volume :

Issue :

Pages :

1319-25

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 25 June 2010

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Bibliography

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