Abstract :
[en] The conformation of calcium complexes formed with meglitinide and its
hypoglycemic analogs KAD-1229, A-4166, S 3075 and repaglinide was analyzed by a
semi-empirical procedure, which includes calculation of the molecular
hydrophobicity potential. The calcium complexes formed with KAD-1229, A-4166,
repaglinide or its enantiomer, displayed favourable attributes to act as
ionophores. Such was not the case for the poorly efficient insulinotropic agent
meglitinide and the biologically inactive enantiomer of A-4166. The configuration
of the calcium complex formed with S 3075 also failed to display the features
required for a high ionophoretic capacity.
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