Abstract :
[en] A continuous membrane model (IMPALA) was previously developed to predict how
hydrophobic spans of proteins insert in membranes (Mol. Mod. 2 (1996) 27). Using
that membrane model, we looked for the interactions between several hydrophobic
spans. We used the glycophorin A dimer as an archetype of polytopic protein to
validate the approach. We find that the native complex do not dislocate when it
is submitted to a 10(5) steps optimisation whereas separated spans converge back
to a native-like complex in the same conditions. We also observe that IMPALA
restraints are not strictly mandatory but do increase the efficiency of the
procedure.
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