New Functions of Stromal Proteases and Their Inhibitors in Tumor Progression

Noël, Agnès; Albert, V.; Bajou, Khalid; Bisson, C.; Devy, L.; Frankenne, Francis; Maquoi, Erik; Masson, Véronique; Sounni, Nor Eddine; Foidart, Jean-Michel

doi:10.1016/s1055-3207(18)30073-5

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New Functions of Stromal Proteases and Their Inhibitors in Tumor Progression

Noël, Agnès; Albert, V.; Bajou, Khalid et al.

2001 • In Surgical Oncology Clinics of North America, 10 (2), p. 417-32

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https://hdl.handle.net/2268/63567

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10.1016/s1055-3207(18)30073-5

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11382595

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Abstract :

[en] Acquisition of invasive metastatic potential through protease expression is a key event in tumor progression. In carcinomas, the production of metalloproteinases and serine proteinases is regulated by a cross talk between stromal cells and cancer cells. Paradoxically, high rather than low levels of their inhibitors predict poor survival of patients suffering from a variety of cancers. Recent observations suggest a much more complex role of these inhibitors in tumor progression than expected initially.

Disciplines :

Biochemistry, biophysics & molecular biology

Author, co-author :

Noël, Agnès ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biologie cellulaire et moléculaire appliquée à l'homme

Albert, V.

Bajou, Khalid ; Université de Liège - ULiège > Département des sciences de la vie > Biologie et génétique moléculaire

Bisson, C.

Devy, L.

Frankenne, Francis

Maquoi, Erik ; Université de Liège - ULiège > Département des sciences cliniques > Labo de biologie des tumeurs et du développement

Masson, Véronique ; Centre Hospitalier Universitaire de Liège - CHU > Gynécologie-Obstétrique CHR

Sounni, Nor Eddine ; Université de Liège - ULiège > Département des sciences cliniques > Labo de biologie des tumeurs et du développement

Foidart, Jean-Michel ; Université de Liège - ULiège > Département des sciences cliniques > Gynécologie - Obstétrique

Language :

English

Title :

New Functions of Stromal Proteases and Their Inhibitors in Tumor Progression

Publication date :

April 2001

Journal title :

Surgical Oncology Clinics of North America

ISSN :

1055-3207

Publisher :

W.B. Saunders

Volume :

Issue :

Pages :

417-32

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 24 June 2010

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