Distribution Of Hydrophobic Residues Is Crucial For The Fusogenic Properties Of The Ebola Virus Gp2 Fusion Peptide

[en] The lipid-destabilizing properties of the N-terminal domain of the GP2 of Ebola virus were investigated. Our results suggest that the domain of Ebola virus needed for fusion is shorter than that previously reported. The fusogenic properties of this domain are related to its oblique orientation at the lipid/water interface owing to an asymmetric distribution of the hydrophobic residues when helical.

Disciplines :

Biochemistry, biophysics & molecular biology

Author, co-author :

Adam, B.

Lins, Laurence ; Université de Liège - ULiège > Gembloux Agro-Bio Tech

Stroobant, V.

Thomas, Annick ; Université de Liège - ULiège > Chimie et bio-industries > Centre de Bio. Fond. - Section de Biologie moléc. et numér.

Brasseur, Robert ; Université de Liège - ULiège > Gembloux Agro-Bio Tech

Language :

English

Title :

Distribution Of Hydrophobic Residues Is Crucial For The Fusogenic Properties Of The Ebola Virus Gp2 Fusion Peptide

Publication date :

2004

Journal title :

Journal of Virology

ISSN :

0022-538X

eISSN :

1098-5514

Publisher :

American Society for Microbiology, Washington, United States - District of Columbia

Volume :

Issue :

Pages :

2131-2136
2131-6

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 24 June 2010

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Bibliography

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