Article (Scientific journals)
Structural Polymorphism Of Two Cpp: An Important Parameter Of Activity
Deshayes, S.; Decaffmeyer, Marc; Brasseur, Robert et al.
2008In Biochimica et Biophysica Acta. Biomembranes, 1778 (5), p. 1197-1205
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Abstract :
[en] Despite numerous investigations, the important structural features of Cell Penetrating Peptides (CPPs) remain unclear as demonstrated by the difficulties encountered in designing new molecules. In this study, we focused our interest on Penetratin and Transportan and several of their variants. Penetratin W48F and Penetratin W48F/W56F exhibit a reduced and a complete lack of cellular uptake, respectively; TP07 and TP10 present a similar cellular uptake as Transportan and TP08, TP13 and TP15 display no or weak internalization capacity. We applied the algorithmic method named PepLook to analyze the peptide polymorphism. The study reveals common conformational characteristics for the CPPs and their permeable variants: they all are polymorphic. Negative, non permeable, mutants share the opposite feature since they are monomorphic. Finally, we support the hypothesis that structural polymorphism may be crucial since it provides peptides with the possibility of adapting their conformation to medium hydrophobicity and or to partner diversity.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Deshayes, S.
Decaffmeyer, Marc ;  Université de Liège - ULiège > Gembloux Agro-Bio Tech
Brasseur, Robert ;  Université de Liège - ULiège > Gembloux Agro-Bio Tech
Thomas, Annick ;  Université de Liège - ULiège > Chimie et bio-industries > Centre de Bio. Fond. - Section de Biologie moléc. et numér.
Language :
English
Title :
Structural Polymorphism Of Two Cpp: An Important Parameter Of Activity
Publication date :
2008
Journal title :
Biochimica et Biophysica Acta. Biomembranes
ISSN :
0005-2736
Publisher :
Elsevier, Netherlands
Volume :
1778
Issue :
5
Pages :
1197-1205
1197-205
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 23 June 2010

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