Reference : Tumor collagenase stimulatory factor (TCSF) expression and localization in human lung...
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/2268/63087
Tumor collagenase stimulatory factor (TCSF) expression and localization in human lung and breast cancers.
English
Polette, M. [ > > ]
Gilles, Christine mailto [Université de Liège - ULiège > Département des sciences cliniques > Labo de biologie des tumeurs et du développement >]
Marchand, V. [ > > ]
Lorenzato, M. [ > > ]
Toole, B. [ > > ]
Tournier, J. M. [ > > ]
Zucker, S. [ > > ]
Birembaut, P. [ > > ]
1997
Journal of Histochemistry and Cytochemistry
Histochemical Society
45
5
703-9
Yes (verified by ORBi)
International
0022-1554
1551-5044
New York
NY
[en] TCSF ; metalloproteinases ; tumor invasion
[en] Tumor cell-derived collagenase stimulatory factor (TCSF) stimulates in vitro the biosynthesis of various matrix metalloproteinases involved in tumor invasion, such as interstitial collagenase, gelatinase A, and stromelysin 1. The expression of TCSF mRNAs was studied in vivo, using in situ hybridization and Northern blotting analysis, in seven normal tissues and in 22 squamous cell carcinomas of the lung, and in seven benign proliferations and in 22 ductal carcinomas of the mammary gland. By in situ hybridization, TCSF mRNAs were detected in 40 of 44 carcinomas, in pre-invasive and invasive cancer cells of both lung and breast cancers. TCSF mRNAs and gelatinase A mRNAs were both visualized in the same areas in serial sections in breast cancers, and were expressed by different cells, tumor cells, and fibroblasts. The histological results were confirmed by Northern blot analysis, which showed a higher expression of TCSF mRNAs in cancers than in benign and normal tissues. These observations support the hypothesis that TCSF is an important factor in lung and breast tumor progression.
http://hdl.handle.net/2268/63087
10.1177/002215549704500508

File(s) associated to this reference

Fulltext file(s):

FileCommentaryVersionSizeAccess
Open access
Polette M JHC 1997.pdfPublisher postprint413.86 kBView/Open

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.