Article (Scientific journals)
The in-vitro antimicrobial activity of some medicinal plants against beta-lactam-resistant bacteria
Gangoue Pieboji, Joseph; Eze, N.; Ngongang Djintchui, A. et al.
2009In Journal of Infection in Developing Countries, 3 (9), p. 671-80
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Keywords :
Anti-Bacterial Agents/isolation & purification/*pharmacology; Bacteria/*drug effects; Microbial Sensitivity Tests/methods; Plant Bark/chemistry; Plant Extracts/isolation & purification/*pharmacology; Plant Leaves/chemistry; Plant Stems/chemistry; Plants, Medicinal/*chemistry; *beta-Lactam Resistance
Abstract :
[en] BACKGROUND: In effort to identify novel bacterial agents, this study was initiated to evaluate the antimicrobial properties of 17 crude extracts from 12 medicinal plants against beta-lactam-resistant bacteria. METHODOLOGY: The antimicrobial activities of plant extracts were evaluated against clinically proved beta-lactam-resistant bacteria (Klebsiella pneumoniae, Klebsiella oxytoca, Enterobacter cloacae, Serratia marcescens, Acinetobacter baumannii, Staphylococcus aureus and Enterococcus sp.) and reference strains of bacteria (Escherichia coli ATCC 35218, Enterobacter aerogenes ATCC 29751, E. aerogenes ATCC 13048, Pseudomonas aeruginosa ATCC 27853 and Enterococcus hirae ATCC 9790) by using disc-diffusion and agar-dilution assays. RESULTS: The crude plant extracts demonstrated broad spectrum activity against all bacteria tested with inhibition zones in the range of 8-30 mm. The minimal inhibitory concentration (MIC) values of different plant extracts against the tested bacteria were found to range from or= 10 mg ml(-1). The most active plant extracts were from Dortenia picta and Bridelia micrantha (MIC: 1.25-10 mg ml(-1)) on beta-lactam-resistant Gram-negative bacilli and the extracts from B. micrantha, Mallotus oppositifolius, Garcinia lucida, Garcinia. kola, Campylospermum densiflorum (leaves) and C. zenkeri (root) on beta-lactam-resistant Gram-positive cocci (MIC:
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Gangoue Pieboji, Joseph ;  Université de Liège - ULiège > Centre d'ingénierie des protéines
Eze, N.
Ngongang Djintchui, A.
Ngameni, B.
Tsabang, N.
Pegnyemb, D. E.
Biyiti, L.
Ngassam, P.
Koulla-Shiro, S.
Galleni, Moreno ;  Université de Liège - ULiège > Département des sciences de la vie > Macromolécules biologiques
Language :
English
Title :
The in-vitro antimicrobial activity of some medicinal plants against beta-lactam-resistant bacteria
Publication date :
2009
Journal title :
Journal of Infection in Developing Countries
ISSN :
2036-6590
eISSN :
1972-2680
Publisher :
Open Learning on Enteric Pathogens, Italy
Volume :
3
Issue :
9
Pages :
671-80
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
2009/10/28
Available on ORBi :
since 21 June 2010

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